N-(5-allyl-2-(2,4-difluorophenyl)-7,7-difluoro-6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-yl)cyclopropanecarboxamide

Base Information

• Chemical Name: N-(5-allyl-2-(2,4-difluorophenyl)-7,7-difluoro-6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-yl)cyclopropanecarboxamide
• CAS No.: 1451076-42-8
• Molecular Formula: C₂₆H₂₄F₄N₄O₂
• Molecular Weight: 500.496
• Mol file: 1451076-42-8.mol

Synonyms:N-(5-allyl-2-(2,4-difluorophenyl)-7,7-difluoro-6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-yl)cyclopropanecarboxamide

Chemical Property of N-(5-allyl-2-(2,4-difluorophenyl)-7,7-difluoro-6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-yl)cyclopropanecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(5-allyl-2-(2,4-difluorophenyl)-7,7-difluoro-6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-yl)cyclopropanecarboxamide

There total 4 articles about N-(5-allyl-2-(2,4-difluorophenyl)-7,7-difluoro-6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-yl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

5-allyl-7,7-difluoro-2-(2,4-difluorophenyl)-6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-amine (1451076-36-0) + cyclopropanecarboxylic acid chloride (4023-34-1) → N-(5-allyl-2-(2,4-difluorophenyl)-7,7-difluoro-6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-yl)cyclopropanecarboxamide (1451076-42-8)

Guidance literature:

With pyridine; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.tetlet.2013.07.076

Reference yield:

3-[(prop-2-en-1-yl)amino]propanenitrile (34508-81-1) → N-(5-allyl-2-(2,4-difluorophenyl)-7,7-difluoro-6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-yl)cyclopropanecarboxamide (1451076-42-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: methanol / 20 °C / Inert atmosphere

2.1: zinc; chloro-trimethyl-silane / tetrahydrofuran / 0.17 h / Inert atmosphere

2.2: 12 h / 20 °C / Inert atmosphere

3.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 13 h / -78 - 20 °C / Inert atmosphere

4.1: ethanol / Reflux; Inert atmosphere

5.1: pyridine / 0 - 20 °C / Inert atmosphere

With pyridine; n-butyllithium; chloro-trimethyl-silane; diisopropylamine; zinc; In tetrahydrofuran; methanol; ethanol; hexane; 2.1: |Mannich Aminomethylation / 3.1: |Dieckmann Condensation;

DOI:10.1016/j.tetlet.2013.07.076

Reference yield:

ethyl 3-(N-(2-cyanoethyl)allylamino)-2,2-difluoro-3-(4-methoxyphenyl)propanoate (1451076-34-8) → N-(5-allyl-2-(2,4-difluorophenyl)-7,7-difluoro-6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-yl)cyclopropanecarboxamide (1451076-42-8)

Guidance literature:

Multi-step reaction with 3 steps

1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 13 h / -78 - 20 °C / Inert atmosphere

2: ethanol / Reflux; Inert atmosphere

3: pyridine / 0 - 20 °C / Inert atmosphere

With pyridine; n-butyllithium; diisopropylamine; In tetrahydrofuran; ethanol; hexane; 1: |Dieckmann Condensation;

DOI:10.1016/j.tetlet.2013.07.076

upstream raw materials:

5-allyl-7,7-difluoro-2-(2,4-difluorophenyl)-6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-amine

cyclopropanecarboxylic acid chloride

3-[(prop-2-en-1-yl)amino]propanenitrile

ethyl 3-(N-(2-cyanoethyl)allylamino)-2,2-difluoro-3-(4-methoxyphenyl)propanoate