34508-81-1Relevant academic research and scientific papers
6-MEMBERED URACIL ISOSTERES
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Paragraph 0819, (2018/06/12)
Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
AMINO SULFONYL COMPOUNDS
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Paragraph 0533, (2018/06/12)
Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
URACIL CONTAINING COMPOUNDS
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Paragraph 0754, (2018/07/31)
Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
Synthesis and Structure of [Cu(Hapn)]NO3]NO3, [Cu(Hapn)(H2O)2]SiF6, [Cu(Hapn)(H2O)BF4]BF4 · H2O and [Cu(Hapn)(NH2SO3)2] π-complexes (apn = 3-(prop-2-en-1-ylamino)propanenitrile)
Luk'Yanov, Mykhailo,Goreshnik, Evgeny,Kinzhybalo, Vasyl,Mys'kiv, Marian
, p. 208 - 214 (2017/04/01)
Four copper(I) π-complexes: [Cu(Hapn)NO3]NO3 (1), [Cu(Hapn)(H2O)2]SiF6 (2), [Cu(Hapn)(H2O)BF4]BF4·H2O (3) and [Cu(Hapn)(NH2SO3)2] (4) were prepared using alternating-current electrochemical technique, starting from alcohol solutions of 3-(prop-2-en-1-ylamino)propanenitrile (apn) titrated with appropriate acid and copper(II) salts (Cu(NO3)2 · 3H2O, CuSiF6 · 4H2O, Cu(BF4)2 · 6H2O or Cu(NH2SO3)2 · xH2O, respectively). Obtained compounds were characterized by single-crystal X-ray diffraction and partially by IR spectroscopy. In the structures of complexes 1, 2 and 4 Cu(I) cation possesses a tetrahedral environment formed by the C=C bond of one organic cation Hapn, the N atom of cyano group from another Hapn moiety, and two O atoms (from NO3- anions in 1, from H2O molecules in 2) or N atoms (NH2SO3- anions in 4). In compound 3 strongly pronounced trigonal-pyramidal coordination environment of Cu(I) is formed by a mid-point of C=C-bond of one Hapn cation, nitrogen atom (of cyano group) of another Hapn unit, O atom of H2O molecule in the basal plane, and F atom of BF4- anion at the apical position.
DEOXYURIDINE TRIPHOSPHATASE INHIBITORS
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Paragraph 0400-0401, (2017/01/26)
Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
DEOXYURIDINE TRIPHOSPHATASE INHIBITORS CONTAINING CYCLOPROPANO LINKAGE
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Paragraph 0370; 0371, (2017/02/09)
Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
Synthesis and biological evaluation of tetrahydropyridinepyrazoles ('PFPs') as inhibitors of STAT3 phosphorylation
Revanna,Srinivasa,Li, Feng,Siveen, Kodappully Sivaraman,Dai, Xiaoyun,Swamy, Shivananju Nanjunda,Bhadregowda,Sethi, Gautam,Mantelingu,Bender, Andreas,Ks, Rangappa
supporting information, p. 32 - 40 (2014/01/06)
The transcription factor STAT3 is constitutively overexpressed in many human tumors and hence represents a putative target for anticancer drug design. In this work, we describe the synthesis and biological evaluation of a novel chemotype, pyridine-fused p
Convenient synthesis of novel N-(5-allyl-7,7-difluoro)-4,5,6,7-tetrahydro- 2H-indazol-3-yl)-carboxymides
Revanna, Chigalli N.,Raghavendra, Goravanahalli M.,Nandeesh, Kebbahalli N.,Bhadregowda, Doddamedur G.,Rangappa, Kanchugarakoppal S.,Mantelingu, Kempegowda
supporting information, p. 5224 - 5226 (2013/09/02)
5-Allyl-7,7-difluoro-2-(2,4-difluorophenyl)-6-(4-methoxyphenyl)-4,5,6, 7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-amine represents a fluorinated heterocyclic scaffold, potentially attractive. It was synthesized via Michael addition, Mannich reaction of the
π-Complexes of copper(I) halides with 3-(allylamino)-(C3H 5NHC2H4CN, Apn) and 3-(diallylamino)-((C3H 5)2NC2H4CN, dapn)-propanenitrile. Syntheses and crystal structures of compounds [CuCl(Apn)], [(H+Apn)Cu2Cl 3], [(H+dapn)CuCl2], and [(H+dapn)CuBr2]
Luk'yanov,Pavlyuk,Mys'kiv
experimental part, p. 86 - 91 (2012/07/14)
The π-complexes [CuCl(C3H5NHC2H4CN)] (I), [(C 3H5NH2C2H4CN)Cu2Cl3] (II), [((C3H5)2NHC2H 4CN)CuCl2] (III), and [((C3H5)2NHC2H4CN)CuBr2] (IV) are obtained as single crystals by the ac electrochemical synthesis on copper wire electrodes from ethanolic solutions of 3-(allylamino)propanenitrile, 3-(diallylamino)propanenitrile, and CuX2 (X = Cl, Br). Their crystal structures are determined. The crystals of compounds I, III, and IV are monoclinic, space group P21/c, Z = 4. The crystals of compound II are triclinic, space group P1, Z = 2. The unit cell parameters are a = 11.125(4), b = 8.769(4), c = 8.570(4) A, β = 90.94(4)°, V = 835.9(6) A3 (I); a = 6.2566(4), b = 7.5975(6), c = 11.1251(8) A, α = 90.896(6)°, β = 92.827(5)°, γ = 94.340(5)°, V = 526.57(7) A3 (II); a= 11.656(4), b= 6.992(4), c = 14.681(5) A, β = 100.89(4)°, V = 1174.9(9) A3 (III); a = 11.845(4), b = 7.282(4), c= 14.855(5) A, β = 100.37(4)°, V = 1260.4(9) A3 (IV). The coordination mode of the Cu(I) atom in complex I includes two halogen atoms, the C=C bond, and the secondary amine N atom. The coordination environment in isostructural crystals of complexes III and IV is formed by the C=C bond and three halogen atoms as in complex II. Pleiades Publishing, Ltd., 2012.
A one-pot, three-component synthesis of thiazolidine-2-thiones
Ziyaei-Halimehjani, Azim,Marjani, Katayoun,Ashouri, Akram
body text, p. 3490 - 3492 (2012/08/27)
An efficient method for the synthesis of thiazolidine-2-thiones is described via regiospecific iodocyclization of an allyl amine, carbon disulfide, and iodine. Dehydrohalogenation of the iodo-derivatives gives thiazole-2(3H)-thiones. In addition, nucleoph
