ethyl 7--3-hydroxy-3-methyl-trans-4-heptenoate

Base Information

• Chemical Name: ethyl 7--3-hydroxy-3-methyl-trans-4-heptenoate
• CAS No.: 75677-21-3
• Molecular Formula: C₂₃H₂₇FO₄
• Molecular Weight: 386.463

Synonyms:ethyl 7--3-hydroxy-3-methyl-trans-4-heptenoate

Chemical Property of ethyl 7--3-hydroxy-3-methyl-trans-4-heptenoate

Chemical Property:

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Technology Process of ethyl 7--3-hydroxy-3-methyl-trans-4-heptenoate

There total 2 articles about ethyl 7--3-hydroxy-3-methyl-trans-4-heptenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.3%

6--trans-3-hexen-2-one (75676-95-8) + ethyl bromoacetate (105-36-2) → ethyl 7--3-hydroxy-3-methyl-trans-4-heptenoate (75677-21-3)

Guidance literature:

With zinc; In benzene; for 1h; Heating;

DOI:10.1248/cpb.28.1509

Reference yield:

3-[4-(4-Fluoro-benzyloxy)-phenyl]-propionaldehyde (75677-06-4) → ethyl 7--3-hydroxy-3-methyl-trans-4-heptenoate (75677-21-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 50percent NaH / tetrahydrofuran / 2 h / -20 °C

2: 94.3 percent / Zn / benzene / 1 h / Heating

With sodium hydride; zinc; In tetrahydrofuran; benzene;

DOI:10.1248/cpb.28.1509

Reference yield:

ethyl 7--3-hydroxy-3-methyl-trans-4-heptenoate (75677-21-3) → (E)-7-[4-(4-Fluoro-benzyloxy)-phenyl]-3-hydroxy-3-methyl-hept-4-enoic acid

Guidance literature:

With sodium hydroxide; In methanol;

DOI:10.1248/cpb.28.1509

upstream raw materials:

6--trans-3-hexen-2-one

ethyl bromoacetate

3-[4-(4-Fluoro-benzyloxy)-phenyl]-propionaldehyde

Downstream raw materials:

5H-r,7--cis-3-hydroxy-trans-3-methylheptan-5-olide

5H-r,cis-4-bromo-7--cis-3-hydroxy-trans-3-methylheptan-5-olide

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