2-adamantan-1-ylmethyl-5-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 2-adamantan-1-ylmethyl-5-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester
• CAS No.: 269070-78-2
• Molecular Formula: C₂₄H₂₉NO₂
• Molecular Weight: 363.5
• Mol file: 269070-78-2.mol

Synonyms:2-adamantan-1-ylmethyl-5-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester

Chemical Property of 2-adamantan-1-ylmethyl-5-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-adamantan-1-ylmethyl-5-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester

There total 3 articles about 2-adamantan-1-ylmethyl-5-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

4-Adamantan-1-yl-3-oxo-2-(2-oxo-2-phenyl-ethyl)-butyric Acid Ethyl Ester (269070-77-1) → 2-adamantan-1-ylmethyl-5-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester (269070-78-2)

Guidance literature:

With ammonium acetate; acetic acid; at 80 ℃; for 24h;

DOI:10.1021/jm049069y

Reference yield:

4-adamantan-1-yl-3-oxobutyric acid ethyl ester (33566-14-2) → 2-adamantan-1-ylmethyl-5-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester (269070-78-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 46 percent / NaI; K₂CO₃ / acetone / 36 h / Heating

2: 71 percent / NH₄OAc; AcOH / 24 h / 80 °C

With ammonium acetate; potassium carbonate; acetic acid; sodium iodide; In acetone;

DOI:10.1021/jm049069y

Reference yield:

α-bromoacetophenone (70-11-1) → 2-adamantan-1-ylmethyl-5-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester (269070-78-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 46 percent / NaI; K₂CO₃ / acetone / 36 h / Heating

2: 71 percent / NH₄OAc; AcOH / 24 h / 80 °C

With ammonium acetate; potassium carbonate; acetic acid; sodium iodide; In acetone;

DOI:10.1021/jm049069y

upstream raw materials:

4-Adamantan-1-yl-3-oxo-2-(2-oxo-2-phenyl-ethyl)-butyric Acid Ethyl Ester

4-adamantan-1-yl-3-oxobutyric acid ethyl ester

α-bromoacetophenone

Downstream raw materials:

2-Adamantan-1-ylmethyl-1-methyl-5-phenyl-1H-pyrrole-3-carboxylic Acid Ethyl Ester

5-((2-adamantan-1-ylmethyl-5-phenyl-1H-pyrrole-3-carbonyl)amino)isophthalic acid dibenzyl ester

3-[(2-adamantan-1-ylmethyl-5-phenyl-1H-pyrrole-3-carbonyl)-amino]-propionic acid benzyl ester

2-adamantan-1-ylmethyl-5-phenyl-1H-pyrrole-3-carbonyl chloride