2(1H)-Pyrimidinone, 4-amino-1-[(5-oxo-2-pyrrolidinyl)methyl]-, (S)-

Base Information

Chemical Name:2(1H)-Pyrimidinone, 4-amino-1-[(5-oxo-2-pyrrolidinyl)methyl]-, (S)-
CAS No.:109205-50-7
Molecular Formula:C₉H₁₂N₄O₂
Molecular Weight:208.22
Hs Code.:
DSSTox Substance ID:DTXSID801162645

Synonyms:SCHEMBL9219936;DTXSID801162645;2(1H)-Pyrimidinone, 4-amino-1-[(5-oxo-2-pyrrolidinyl)methyl]-, (S)-;109205-50-7

Suppliers and Price of 2(1H)-Pyrimidinone, 4-amino-1-[(5-oxo-2-pyrrolidinyl)methyl]-, (S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2(1H)-Pyrimidinone, 4-amino-1-[(5-oxo-2-pyrrolidinyl)methyl]-, (S)-

Chemical Property:

XLogP3:-1.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:208.09602564
Heavy Atom Count:15
Complexity:361

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC(=O)NC1CN2C=CC(=NC2=O)N
Isomeric SMILES:C1CC(=O)N[C@@H]1CN2C=CC(=NC2=O)N

Technology Process of 2(1H)-Pyrimidinone, 4-amino-1-[(5-oxo-2-pyrrolidinyl)methyl]-, (S)-

There total 1 articles about 2(1H)-Pyrimidinone, 4-amino-1-[(5-oxo-2-pyrrolidinyl)methyl]-, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17342-08-4
(S)-Pyroglutaminol

: 109205-50-7
(S)-4-amino-1-<(5-oxo-2-pyrrolidinyl)methyl>-2(1H)-pyrimidinone

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / N-methylimidazole / CH₂Cl₂ / 24 h / 0 °C

2: 62 percent / potassium tert-butoxide / dimethylsulfoxide / 18 h / 25 °C

With 1-methyl-1H-imidazole; potassium tert-butylate; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jo00021a010

Reference yield: 99.0%

: 98-88-4
benzoyl chloride

: 109205-50-7
(S)-4-amino-1-<(5-oxo-2-pyrrolidinyl)methyl>-2(1H)-pyrimidinone

: 135697-09-5
(S)-N-<1,2-dihydro-2-oxo-1-<(5-oxo-2-pyrrolidinyl)methyl>-4-pyrimidinyl>benzamide

Guidance literature:: With pyridine; for 8h;
DOI:10.1021/jo00021a010

Reference yield:

: 109205-50-7
(S)-4-amino-1-<(5-oxo-2-pyrrolidinyl)methyl>-2(1H)-pyrimidinone

: 135697-44-8
C₇₀H₉₂N₁₄O₁₁

Guidance literature:: Multi-step reaction with 9 steps

1: dimethylformamide / 8 h / 40 °C

2: 4-(dimethylamino)pyridine, Et₃N / CH₂Cl₂

3: 79 percent / (p-toluenesulfonyl)hydrazine / CH₂Cl₂ / 24 h / 25 °C

4: 83 percent / pyridine / 8 h / Ambient temperature

5: 73 percent / 1 M LiOH / tetrahydrofuran; 2-methyl-propan-2-ol; ethanol; H₂O / 0.13 h

6: 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide methiodide, 4-(dimethylamino)pyridine / CH₂Cl₂

7: 65 percent / Et₃N / dimethylformamide / 12 h / Ambient temperature

With pyridine; dmap; lithium hydroxide; 3-{[(ethylimino)methylene]-amino}-N,N,N-trimethyl-1-propanaminium iodide; triethylamine; toluene-4-sulfonic acid hydrazide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jo00021a010