C₂₇H₃₂FN₃O₃

Base Information

Chemical Name:C₂₇H₃₂FN₃O₃
CAS No.:1254367-72-0
Molecular Formula:C₂₇H₃₂FN₃O₃
Molecular Weight:465.568
Hs Code.:

C<sub>27</sub>H<sub>32</sub>FN<sub>3</sub>O<sub>3</sub>

Synonyms:C₂₇H₃₂FN₃O₃

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Chemical Property of C₂₇H₃₂FN₃O₃

Chemical Property:

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Technology Process of C₂₇H₃₂FN₃O₃

There total 12 articles about C₂₇H₃₂FN₃O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 53369-71-4
N,N,2,2-tetramethyl-1,3-propanediamine

: 1254367-70-8
phenyl 3-(benzyloxy)-2-bromo-6-fluoro-5-methylisonicotinate

: 1254367-72-0
C₂₇H₃₂FN₃O₃

Guidance literature:: With caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; at 70 ℃; for 1.5h;

Reference yield:

: 1254367-40-2
phenyl 3-(benzyloxy)-2,6-dibromo-5-methylisonicotinate

: 1254367-72-0
C₂₇H₃₂FN₃O₃

Guidance literature:: Multi-step reaction with 3 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl carbazate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere

2: pyridine; hydrogen fluoride; sodium nitrite / 0 - 20 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tetrahydrofuran; 1,4-dioxane / 1.5 h / 70 °C / Inert atmosphere

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl carbazate; hydrogen fluoride; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium nitrite; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/jm1015389

Reference yield:

: 1254367-44-6
C₂₀H₁₆BrNO₄

: 1254367-72-0
C₂₇H₃₂FN₃O₃

Guidance literature:: Multi-step reaction with 4 steps

1: phosphorus(V) oxybromide / toluene / 0.75 h / 100 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl carbazate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere

3: pyridine; hydrogen fluoride; sodium nitrite / 0 - 20 °C

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tetrahydrofuran; 1,4-dioxane / 1.5 h / 70 °C / Inert atmosphere

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl carbazate; hydrogen fluoride; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium nitrite; phosphorus(V) oxybromide; In tetrahydrofuran; 1,4-dioxane; toluene;
DOI:10.1021/jm1015389