N-{4-[5-(4-fluorophenyl)-4,5-dihydro-1H-3-pyrazolyl]phenyl}-5-chloro-2-methoxybenzamide

Base Information

• Chemical Name: N-{4-[5-(4-fluorophenyl)-4,5-dihydro-1H-3-pyrazolyl]phenyl}-5-chloro-2-methoxybenzamide
• CAS No.: 1042734-59-7
• Molecular Formula: C₂₃H₁₉ClFN₃O₂
• Molecular Weight: 423.874
• Mol file: 1042734-59-7.mol

Synonyms:N-{4-[5-(4-fluorophenyl)-4,5-dihydro-1H-3-pyrazolyl]phenyl}-5-chloro-2-methoxybenzamide

Chemical Property of N-{4-[5-(4-fluorophenyl)-4,5-dihydro-1H-3-pyrazolyl]phenyl}-5-chloro-2-methoxybenzamide

Chemical Property:

Purity/Quality:

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Technology Process of N-{4-[5-(4-fluorophenyl)-4,5-dihydro-1H-3-pyrazolyl]phenyl}-5-chloro-2-methoxybenzamide

There total 1 articles about N-{4-[5-(4-fluorophenyl)-4,5-dihydro-1H-3-pyrazolyl]phenyl}-5-chloro-2-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

N-[4-(4-fluorocinnamoyl)phenyl]-5-chloro-2-methoxybenzamide → N-{4-[5-(4-fluorophenyl)-4,5-dihydro-1H-3-pyrazolyl]phenyl}-5-chloro-2-methoxybenzamide (1042734-59-7)

Guidance literature:

With hydrazine hydrate; In 1,4-dioxane; for 2h; Heating;

DOI:10.1007/s00706-007-0701-7

Reference yield: 80.0%

N-{4-[5-(4-fluorophenyl)-4,5-dihydro-1H-3-pyrazolyl]phenyl}-5-chloro-2-methoxybenzamide (1042734-59-7) + acetyl chloride (75-36-5) → N-{4-[1-acetyl-5-(4-fluorophenyl)-4,5-dihydro-1H-3-pyrazolyl]phenyl}-5-chloro-2-methoxybenzamide

Guidance literature:

In 1,4-dioxane; at 20 ℃; for 5h;

DOI:10.1007/s00706-007-0701-7

Reference yield: 56.0%

morpholine (110-91-8,99108-56-2) + N-{4-[5-(4-fluorophenyl)-4,5-dihydro-1H-3-pyrazolyl]phenyl}-5-chloro-2-methoxybenzamide (1042734-59-7) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → N-{4-[5-(4-fluorophenyl)-1-morpholinomethyl-4,5-dihydro-1H-3-pyrazolyl]phenyl}-5-chloro-2-methoxybenzamide

Guidance literature:

In ethanol; for 2h; Heating;

DOI:10.1007/s00706-007-0701-7