Technology Process of Boc-Tyr(OH)-D-Ala-Gly-benzylamine
There total 4 articles about Boc-Tyr(OH)-D-Ala-Gly-benzylamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
benzotriazol-1-ol; dicyclohexyl-carbodiimide;
In
N,N-dimethyl-formamide;
at 0 - 25 ℃;
for 52h;
DOI:10.1021/jm00184a010
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.7 g / H2 / 10percent Pd/C / methanol; acetic acid; H2O / 2068.6 Torr
2: 54 percent / 1-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / dimethylformamide / 52 h / 0 - 25 °C
With
hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
methanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00184a010
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 100 percent / 4 N aq. HCl / dioxane / 3 h / 25 °C
2: 46 percent / Et3N, 1-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / dimethylformamide / 124 h / 0 - 25 °C
3: 1.7 g / H2 / 10percent Pd/C / methanol; acetic acid; H2O / 2068.6 Torr
4: 54 percent / 1-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / dimethylformamide / 52 h / 0 - 25 °C
With
hydrogenchloride; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
1,4-dioxane; methanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00184a010
