(2R,4R)-2-phenyl-4-vinylthiazolidine-3-tert-butyl carboxylate

Base Information

• Chemical Name: (2R,4R)-2-phenyl-4-vinylthiazolidine-3-tert-butyl carboxylate
• CAS No.: 1068134-56-4
• Molecular Formula: C₁₆H₂₁NO₂S
• Molecular Weight: 291.414
• Mol file: 1068134-56-4.mol

Synonyms:(2R,4R)-2-phenyl-4-vinylthiazolidine-3-tert-butyl carboxylate

Chemical Property of (2R,4R)-2-phenyl-4-vinylthiazolidine-3-tert-butyl carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,4R)-2-phenyl-4-vinylthiazolidine-3-tert-butyl carboxylate

There total 1 articles about (2R,4R)-2-phenyl-4-vinylthiazolidine-3-tert-butyl carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

Methyltriphenylphosphonium bromide (1779-49-3) + (2R,4R)-4-formyl-2-phenylthiazolidine-3-carboxylic acid tert-butyl ester (157020-34-3) → (2R,4R)-2-phenyl-4-vinylthiazolidine-3-tert-butyl carboxylate (1068134-56-4)

Guidance literature:

Methyltriphenylphosphonium bromide; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃;

(2R,4R)-4-formyl-2-phenylthiazolidine-3-carboxylic acid tert-butyl ester; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1021/ol8016947

Reference yield: 87.0%

(2R,4R)-2-phenyl-4-vinylthiazolidine-3-tert-butyl carboxylate (1068134-56-4) + N-methyl-12-tridecenamide → C28H44N2O3S

Guidance literature:

With Hoveyda-Grubbs catalyst second generation; In dichloromethane; Reflux; Inert atmosphere;

DOI:10.1021/acs.jnatprod.0c01317

Reference yield: 84.0%

N-methylundec-10-enamide (50278-84-7) + (2R,4R)-2-phenyl-4-vinylthiazolidine-3-tert-butyl carboxylate (1068134-56-4) → tert-Butyl (2R,4R,4E)-4-(11-(methylamino)-11-oxoundec-1-enyl)-2-phenylthiazolidine -3-carboxylate

Guidance literature:

With Hoveyda-Grubbs catalyst second generation; In chloroform; for 18h; Reflux; Inert atmosphere;

DOI:10.1021/acs.jnatprod.0c01317

upstream raw materials:

Methyltriphenylphosphonium bromide

(2R,4R)-4-formyl-2-phenylthiazolidine-3-carboxylic acid tert-butyl ester

Downstream raw materials:

(2R,4R)-3-tert-butoxycarbonyl-4-((E)-11-methoxy-11-oxoundec-1-enyl)-2-phenylthiazolidine