4-dimethylamino-N-[2-methyl-3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl]benzamide

Base Information

Chemical Name:4-dimethylamino-N-[2-methyl-3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl]benzamide
CAS No.:1147530-84-4
Molecular Formula:C₂₂H₂₉BN₂O₃
Molecular Weight:380.295
Hs Code.:

Synonyms:4-dimethylamino-N-[2-methyl-3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl]benzamide

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Chemical Property of 4-dimethylamino-N-[2-methyl-3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl]benzamide

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Technology Process of 4-dimethylamino-N-[2-methyl-3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl]benzamide

There total 8 articles about 4-dimethylamino-N-[2-methyl-3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 4755-50-4
4-(dimethylamino)benzoyl chloride

: 882678-96-8
2-methyl-3-( 4,4,5,5-tetramethyl[1,3,2]dioxaborolane-2-yl)phenylamine

: 1147530-84-4
4-dimethylamino-N-[2-methyl-3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl]benzamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: N-(3-bromo-2-methylphenyl)-4-(dimethylamino)benzamide

: 73183-34-3
bis(pinacol)diborane

: 1147530-84-4
4-dimethylamino-N-[2-methyl-3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl]benzamide

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 100 ℃; for 8h; Inert atmosphere;
DOI:10.1016/j.ejmech.2017.03.001

Reference yield:

: 73183-34-3
bis(pinacol)diborane

: 1147530-84-4
4-dimethylamino-N-[2-methyl-3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl]benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 1,1'-bis-(diphenylphosphino)ferrocene / 1,4-dioxane / 5 h / Inert atmosphere; Reflux

2: hydrogen; palladium on activated charcoal / ethanol / 6 h / 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

With 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium on activated charcoal; hydrogen; potassium acetate; triethylamine; In 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1021/jm500305p