Cyclopropanecarboxylic acid, 1-amino-2-methyl-, methyl ester, hydrochloride, cis- (9CI)

Base Information

Chemical Name:Cyclopropanecarboxylic acid, 1-amino-2-methyl-, methyl ester, hydrochloride, cis- (9CI)
CAS No.:98259-91-7
Molecular Formula:C₆H₁₁NO₂*ClH
Molecular Weight:165.62
Hs Code.:
Mol file:98259-91-7.mol

Synonyms:Cyclopropanecarboxylicacid, 1-amino-2-methyl-, methyl ester, hydrochloride, cis- (9CI);Cyclopropanecarboxylic acid, 1-amino-2-methyl-, methyl ester, hydrochloride,cis-(?à)-

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Chemical Property of Cyclopropanecarboxylic acid, 1-amino-2-methyl-, methyl ester, hydrochloride, cis- (9CI)

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Technology Process of Cyclopropanecarboxylic acid, 1-amino-2-methyl-, methyl ester, hydrochloride, cis- (9CI)

There total 20 articles about Cyclopropanecarboxylic acid, 1-amino-2-methyl-, methyl ester, hydrochloride, cis- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 138571-85-4,138571-86-5,138663-09-9,138663-10-2
N-(tert-butyloxycarbonyl)-1-amino-(E)-2-methylcyclopropanecarboxylic acid methyl ester

: 98259-91-7,138571-90-1,138663-12-4,138663-13-5,156258-66-1
(E)-1-amino-2-methylcyclopropanecarboxylic acid methyl ester hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; a) 0 deg C, 1 h, b) room temperature;
DOI:10.1021/jo00030a009

Reference yield:

: 58561-08-3,112392-65-1,142035-85-6,93267-05-1
(S)-methyl 2-(((tert-butoxy)carbonyl)amino)butanoate

: 98259-91-7,138571-90-1,138663-12-4,138663-13-5,156258-66-1
(Z)-1-amino-2-methylcyclopropanecarboxylic acid methyl ester hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: tert-butyl hypochlorite / NaOCH₃ / methanol / 23 h / 4 °C

2: DBU / CH₂Cl₂ / 5 h / Heating

3: tetrahydrofuran; diethyl ether / 0 °C

4: tetrahydrofuran / Irradiation

5: aq. HCl / dioxane; CH₂Cl₂ / a) 0 deg C, 1 h, b) room temperature

With hydrogenchloride; tert-butylhypochlorite; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium methylate; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane;
DOI:10.1021/jo00030a009