methotrexate α-benzyl ester γ-n-butylamide

Base Information

• Chemical Name: methotrexate α-benzyl ester γ-n-butylamide
• CAS No.: 79640-71-4
• Molecular Formula: C₃₁H₃₇N₉O₄
• Molecular Weight: 599.693
• Mol file: 79640-71-4.mol

Synonyms:methotrexate α-benzyl ester γ-n-butylamide

Chemical Property of methotrexate α-benzyl ester γ-n-butylamide

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of methotrexate α-benzyl ester γ-n-butylamide

There total 1 articles about methotrexate α-benzyl ester γ-n-butylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[(2,4-diaminopteridin-6-ylmethyl)methylamino]benzoic acid (19741-14-1) + L-glutamic acid α-benzyl ester γ-n-butylamide p-toluenesulfonate salt (79640-79-2) → methotrexate α-benzyl ester γ-n-butylamide (79640-71-4)

Guidance literature:

With diethyl cyanophosphonate; triethylamine; Yield given. Multistep reaction; 1.) DMF, 80 deg C, 2 min, 2.) DMF, 80 deg C, 2 h;

DOI:10.1021/jm00144a016

Reference yield: 73.0%

methotrexate α-benzyl ester γ-n-butylamide (79640-71-4) → methotrexate γ-n-butylamide (79640-74-7)

Guidance literature:

With barium dihydroxide; In ethanol; water; Ambient temperature;

DOI:10.1021/jm00144a016

upstream raw materials:

4-[(2,4-diaminopteridin-6-ylmethyl)methylamino]benzoic acid

L-glutamic acid α-benzyl ester γ-n-butylamide p-toluenesulfonate salt

Downstream raw materials:

methotrexate γ-n-butylamide