(R)-ethyl 4-((2-(1'-(3-chlorobenzyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1H-spiro[furo [3,4-d]pyrimidin-5,4'-piperidine]-3(2H_.4H_.7H)-yl)-1-phenylethyl)amino)butanoate

Base Information

• Chemical Name: (R)-ethyl 4-((2-(1'-(3-chlorobenzyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1H-spiro[furo [3,4-d]pyrimidin-5,4'-piperidine]-3(2H_.4H_.7H)-yl)-1-phenylethyl)amino)butanoate
• CAS No.: 1454273-49-4
• Molecular Formula: C₃₉H₄₁ClF₄N₄O₅
• Molecular Weight: 757.225

Synonyms:(R)-ethyl 4-((2-(1'-(3-chlorobenzyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1H-spiro[furo [3,4-d]pyrimidin-5,4'-piperidine]-3(2H_.4H_.7H)-yl)-1-phenylethyl)amino)butanoate

Chemical Property of (R)-ethyl 4-((2-(1'-(3-chlorobenzyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1H-spiro[furo [3,4-d]pyrimidin-5,4'-piperidine]-3(2H_.4H_.7H)-yl)-1-phenylethyl)amino)butanoate

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Technology Process of (R)-ethyl 4-((2-(1'-(3-chlorobenzyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1H-spiro[furo [3,4-d]pyrimidin-5,4'-piperidine]-3(2H_.4H_.7H)-yl)-1-phenylethyl)amino)butanoate

There total 1 articles about (R)-ethyl 4-((2-(1'-(3-chlorobenzyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1H-spiro[furo [3,4-d]pyrimidin-5,4'-piperidine]-3(2H_.4H_.7H)-yl)-1-phenylethyl)amino)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

Ethyl 4-bromobutyrate (2969-81-5) + (R)-3-(2-amino-2-phenylethyl)-1'-(3-chlorobenzyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidine]-2,4(3H,7H)-dione (1454272-21-9) → (R)-ethyl 4-((2-(1'-(3-chlorobenzyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1H-spiro[furo [3,4-d]pyrimidin-5,4'-piperidine]-3(2H.4H.7H)-yl)-1-phenylethyl)amino)butanoate (1454273-49-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 55 ℃; for 12h;

Reference yield: 90.0%

(R)-ethyl 4-((2-(1'-(3-chlorobenzyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1H-spiro[furo [3,4-d]pyrimidin-5,4'-piperidine]-3(2H.4H.7H)-yl)-1-phenylethyl)amino)butanoate (1454273-49-4) → (R)-4-((2-(1'-(3-chlorobenzyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H, 4H, 7H)-yl)-1-phenylethyl)amino)butanoic acid (1454272-81-1)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 20 ℃;

upstream raw materials:

Ethyl 4-bromobutyrate

(R)-3-(2-amino-2-phenylethyl)-1'-(3-chlorobenzyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidine]-2,4(3H,7H)-dione

Downstream raw materials:

(R)-4-((2-(1'-(3-chlorobenzyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H, 4H, 7H)-yl)-1-phenylethyl)amino)butanoic acid

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