trifluoromethanesulfonic acid 6-{tert-butoxycarbonyl-[2-(4-trifluoromethoxyphenyl)ethyl]amino}-2-methoxypyrimidin-4-yl ester

Base Information

Chemical Name:trifluoromethanesulfonic acid 6-{tert-butoxycarbonyl-[2-(4-trifluoromethoxyphenyl)ethyl]amino}-2-methoxypyrimidin-4-yl ester
CAS No.:1334406-60-8
Molecular Formula:C₂₀H₂₁F₆N₃O₇S
Molecular Weight:561.459
Hs Code.:

Synonyms:trifluoromethanesulfonic acid 6-{tert-butoxycarbonyl-[2-(4-trifluoromethoxyphenyl)ethyl]amino}-2-methoxypyrimidin-4-yl ester

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Chemical Property of trifluoromethanesulfonic acid 6-{tert-butoxycarbonyl-[2-(4-trifluoromethoxyphenyl)ethyl]amino}-2-methoxypyrimidin-4-yl ester

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Technology Process of trifluoromethanesulfonic acid 6-{tert-butoxycarbonyl-[2-(4-trifluoromethoxyphenyl)ethyl]amino}-2-methoxypyrimidin-4-yl ester

There total 5 articles about trifluoromethanesulfonic acid 6-{tert-butoxycarbonyl-[2-(4-trifluoromethoxyphenyl)ethyl]amino}-2-methoxypyrimidin-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1334406-59-5
trifluoromethanesulfonic acid 2-methoxy-6-[2-(4-trifluoromethoxyphenyl)ethylamino]pyrimidin-4-yl ester

: 1334406-60-8
trifluoromethanesulfonic acid 6-{tert-butoxycarbonyl-[2-(4-trifluoromethoxyphenyl)ethyl]amino}-2-methoxypyrimidin-4-yl ester

Guidance literature:: dmap; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield:

: 1334406-58-4
trifluoromethanesulfonic acid 2-methoxy-6-trifluoromethanesulfonyloxypyrimidin-4-yl ester

: 1334406-60-8
trifluoromethanesulfonic acid 6-{tert-butoxycarbonyl-[2-(4-trifluoromethoxyphenyl)ethyl]amino}-2-methoxypyrimidin-4-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

2: dmap / tetrahydrofuran / 3 h / 20 °C

With N-ethyl-N,N-diisopropylamine; dmap; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1758-98-1
2-methoxy-4,6-dihydroxy-pyrimidine

: 1334406-60-8
trifluoromethanesulfonic acid 6-{tert-butoxycarbonyl-[2-(4-trifluoromethoxyphenyl)ethyl]amino}-2-methoxypyrimidin-4-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 1 h / 20 °C

1.2: 1.08 h / 20 °C / Cooling with ice

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

3.1: dmap / tetrahydrofuran / 3 h / 20 °C

With triethylamine; N-ethyl-N,N-diisopropylamine; dmap; In tetrahydrofuran; dichloromethane;