Benzoic acid (S)-1,2-bis-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-oxo-ethyl ester

Base Information

Chemical Name:Benzoic acid (S)-1,2-bis-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-oxo-ethyl ester
CAS No.:189701-89-1
Molecular Formula:C₁₉H₂₄O₇
Molecular Weight:364.395
Hs Code.:

Synonyms:Benzoic acid (S)-1,2-bis-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-oxo-ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzoic acid (S)-1,2-bis-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-oxo-ethyl ester

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Technology Process of Benzoic acid (S)-1,2-bis-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-oxo-ethyl ester

There total 6 articles about Benzoic acid (S)-1,2-bis-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-oxo-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 190008-37-8
Mono-O-benzoyl-1,2;5,6-bis-O-isopropyliden-D-talit

: 189701-89-1
Benzoic acid (S)-1,2-bis-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-oxo-ethyl ester

Guidance literature:: With oxalyl dichloride; TEA; dimethyl sulfoxide; In dichloromethane; at -68 ℃; for 1h;
DOI:10.1021/jo961542v

Reference yield:

: 98-88-4
benzoyl chloride

: 189701-89-1
Benzoic acid (S)-1,2-bis-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-oxo-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) DMAP, 2.) TBAF / 1.) pyridine, 0 deg C, 2.) THF

2: 58 percent / oxalyl chloride, DMSO, TEA / CH₂Cl₂ / 1 h / -68 °C

With dmap; oxalyl dichloride; TEA; tetrabutyl ammonium fluoride; dimethyl sulfoxide; In dichloromethane;
DOI:10.1021/jo961542v

Reference yield:

: 189701-54-0
(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1,2-bis-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethanone

: 189701-89-1
Benzoic acid (S)-1,2-bis-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-oxo-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 45 percent / Zn(BH₄)2 / diethyl ether / 5 h / -15 °C

2: 1.) DMAP, 2.) TBAF / 1.) pyridine, 0 deg C, 2.) THF

3: 58 percent / oxalyl chloride, DMSO, TEA / CH₂Cl₂ / 1 h / -68 °C

With dmap; zinc(II) tetrahydroborate; oxalyl dichloride; TEA; tetrabutyl ammonium fluoride; dimethyl sulfoxide; In diethyl ether; dichloromethane;
DOI:10.1021/jo961542v