diethyl N-<4-<<(2,4-diamino-6-pteridinyl)methyl>propargylamino>benzoyl>-L-glutamate

Base Information

Chemical Name:diethyl N-<4-<<(2,4-diamino-6-pteridinyl)methyl>propargylamino>benzoyl>-L-glutamate
CAS No.:82318-23-8
Molecular Formula:C₂₆H₃₀N₈O₅
Molecular Weight:534.575
Hs Code.:

Synonyms:diethyl N-<4-<<(2,4-diamino-6-pteridinyl)methyl>propargylamino>benzoyl>-L-glutamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl N-<4-<<(2,4-diamino-6-pteridinyl)methyl>propargylamino>benzoyl>-L-glutamate

Chemical Property:

Purity/Quality:

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MSDS Files:: SDS file from LookChem

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Technology Process of diethyl N-<4-<<(2,4-diamino-6-pteridinyl)methyl>propargylamino>benzoyl>-L-glutamate

There total 2 articles about diethyl N-<4-<<(2,4-diamino-6-pteridinyl)methyl>propargylamino>benzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 76858-72-5
diethyl N-(4-(prop-2-ynylamino)benzoyl)-L-glutamate

: 52853-40-4
6-bromomethyl-2,4-diaminopteridine hydrobromide

: 82318-23-8
diethyl N-<4-<<(2,4-diamino-6-pteridinyl)methyl>propargylamino>benzoyl>-L-glutamate

Guidance literature:: In N,N-dimethyl acetamide; 1.) 25 deg C, 18 h, 2.) 60 deg C, 6 h, 3.) 80 deg C, 1 h;
DOI:10.1021/jm00349a024

Reference yield:

: 13726-52-8
diethyl N-(p-aminobenzoyl)-L-glutamate

: 82318-23-8
diethyl N-<4-<<(2,4-diamino-6-pteridinyl)methyl>propargylamino>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 2 steps

1: NaHCO₃ / toluene; ethanol / 16 h / Heating

2: 52 percent / N,N-dimethyl-acetamide / 1.) 25 deg C, 18 h, 2.) 60 deg C, 6 h, 3.) 80 deg C, 1 h

With sodium hydrogencarbonate; In ethanol; N,N-dimethyl acetamide; toluene;
DOI:10.1021/jm00349a024