82318-25-0 Usage
Chemical compound
A substance with a specific molecular structure that has been developed as a potential anti-cancer agent.
Derivative of aminopterin
A folic acid antagonist that interferes with the metabolism of folate, which is essential for cell growth and division.
Propargyl group addition
The addition of a propargyl group to the aminopterin molecule is thought to enhance its ability to target cancer cells while minimizing toxicity to normal cells.
Potential to treat various cancers
Being investigated for its potential to treat different types of cancer, including leukemia, lymphoma, and solid tumors.
Mechanism of action
Inhibiting the activity of enzymes involved in folate metabolism, ultimately leading to the suppression of cancer cell proliferation.
Preclinical model results
Studies have shown promising results in preclinical models, indicating its potential effectiveness against cancer.
Ongoing research
Further research is being conducted to evaluate the safety and efficacy of 10-propargylaminopterin for use in cancer therapy.
Targeting cancer cells
The compound is designed to specifically target cancer cells, potentially reducing harm to healthy cells.
Minimizing toxicity
The propargyl group addition aims to minimize toxicity to normal cells, improving the therapeutic index of the compound.
Folic acid antagonist
As a derivative of aminopterin, 10-propargylaminopterin acts as a folic acid antagonist, disrupting the metabolism of folate in cancer cells.
Check Digit Verification of cas no
The CAS Registry Mumber 82318-25-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,3,1 and 8 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 82318-25:
(7*8)+(6*2)+(5*3)+(4*1)+(3*8)+(2*2)+(1*5)=120
120 % 10 = 0
So 82318-25-0 is a valid CAS Registry Number.
InChI:InChI=1/C22H22N8O5/c1-2-9-30(11-13-10-25-19-17(26-13)18(23)28-22(24)29-19)14-5-3-12(4-6-14)20(33)27-15(21(34)35)7-8-16(31)32/h1,3-6,10,15H,7-9,11H2,(H,27,33)(H,31,32)(H,34,35)(H4,23,24,25,28,29)
82318-25-0Relevant articles and documents
10-Propargylaminopterin and Alkyl Homologues of Methotrexate as Inhibitors of Folate Metabolism
Piper, J. R.,McCaleb, G. S.,Montgomery, J. A.,Kisliuk, R. L.,Gaumont, Y.,Sirotnak, F. M.
, p. 877 - 880 (2007/10/02)
Reported antifolate activity against leukemia L1210 by N-propargylamino>benzoyl>-L-glutamic acid through potent inhibition of thymidylate synthase (EC 2.1.1.45) prompted us to include the propargyl group in a
