[(8R)-3-[2-(2,4-difluorophenyl)thiazol-4-yl]-8-methyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl][4-(2-thienyl)phenyl]methanone

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Chemical Name:[(8R)-3-[2-(2,4-difluorophenyl)thiazol-4-yl]-8-methyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl][4-(2-thienyl)phenyl]methanone
CAS No.:1338373-68-4
Molecular Formula:C₂₆H₁₉F₂N₅OS₂
Molecular Weight:519.599
Hs Code.:

Synonyms:[(8R)-3-[2-(2,4-difluorophenyl)thiazol-4-yl]-8-methyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl][4-(2-thienyl)phenyl]methanone

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Chemical Property of [(8R)-3-[2-(2,4-difluorophenyl)thiazol-4-yl]-8-methyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl][4-(2-thienyl)phenyl]methanone

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Technology Process of [(8R)-3-[2-(2,4-difluorophenyl)thiazol-4-yl]-8-methyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl][4-(2-thienyl)phenyl]methanone

There total 7 articles about [(8R)-3-[2-(2,4-difluorophenyl)thiazol-4-yl]-8-methyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl][4-(2-thienyl)phenyl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 4-(thiophen-2-yl)benzoyl chloride

: (R)-2-(2,4-difluorophenyl)-4-(8-methyl-5,6,7,8-tetrahydro-[1,2,4]-triazolo[4,3-a]pyrazin-3-yl)thiazole

: 1338373-68-4
[(8R)-3-[2-(2,4-difluorophenyl)thiazol-4-yl]-8-methyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl][4-(2-thienyl)phenyl]methanone

Guidance literature:: (R)-2-(2,4-difluorophenyl)-4-(8-methyl-5,6,7,8-tetrahydro-[1,2,4]-triazolo[4,3-a]pyrazin-3-yl)thiazole; With 4-methyl-morpholine; In dichloromethane; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

4-(thiophen-2-yl)benzoyl chloride; In dichloromethane; at 0 - 20 ℃; for 0.166667h; Inert atmosphere;
DOI:10.1021/jm5017413

Reference yield:

: 1383146-20-0
(R)-4-(2,4-dimethoxybenzyl)-3-methylpiperazin-2-one

: 1338373-68-4
[(8R)-3-[2-(2,4-difluorophenyl)thiazol-4-yl]-8-methyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl][4-(2-thienyl)phenyl]methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / dichloromethane / 0.75 h / 15 - 20 °C / Inert atmosphere

2.1: methanol / 8 h / 60 - 70 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 0.25 h / 0 - 20 °C / Inert atmosphere

3.2: 0.5 h / Inert atmosphere

4.1: 4-methyl-morpholine / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere

4.2: 0.17 h / 0 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; sodium carbonate; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1021/jm5017413

Reference yield:

: 1429560-52-0
(R)-1-(2,4-dimethoxybenzyl)-5-ethoxy-6-methyl-1,2,3,6-tetrahydropyrazine

: 1338373-68-4
[(8R)-3-[2-(2,4-difluorophenyl)thiazol-4-yl]-8-methyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl][4-(2-thienyl)phenyl]methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanol / 8 h / 60 - 70 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 0.25 h / 0 - 20 °C / Inert atmosphere

2.2: 0.5 h / Inert atmosphere

3.1: 4-methyl-morpholine / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere

3.2: 0.17 h / 0 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1021/jm5017413