2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]-1-(4-{4-[5-(2-chloro-6-(prop-2-yn-1-yloxy)phenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidin-1-yl)ethanone

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Chemical Name:2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]-1-(4-{4-[5-(2-chloro-6-(prop-2-yn-1-yloxy)phenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidin-1-yl)ethanone
CAS No.:1313009-76-5
Molecular Formula:C₂₇H₂₄ClF₄N₅O₃S
Molecular Weight:610.032
Hs Code.:

2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]-1-(4-{4-[5-(2-chloro-6-(prop-2-yn-1-yloxy)phenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidin-1-yl)ethanone

Synonyms:2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]-1-(4-{4-[5-(2-chloro-6-(prop-2-yn-1-yloxy)phenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidin-1-yl)ethanone

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Chemical Property of 2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]-1-(4-{4-[5-(2-chloro-6-(prop-2-yn-1-yloxy)phenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidin-1-yl)ethanone

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Technology Process of 2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]-1-(4-{4-[5-(2-chloro-6-(prop-2-yn-1-yloxy)phenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidin-1-yl)ethanone

There total 7 articles about 2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]-1-(4-{4-[5-(2-chloro-6-(prop-2-yn-1-yloxy)phenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidin-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 512809-60-8
[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetic acid

: 1313009-76-5
2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]-1-(4-{4-[5-(2-chloro-6-(prop-2-yn-1-yloxy)phenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 °C

2: triethylamine / dichloromethane / 0 - 20 °C

3: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 9 h / 80 °C

With oxalyl dichloride; potassium carbonate; triethylamine; potassium iodide; N,N-dimethyl-formamide; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1313010-08-0
tert-butyl 4-{4-[5-(2-chloro-6-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidine-1-carboxylate

: 1313009-76-5
2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]-1-(4-{4-[5-(2-chloro-6-(prop-2-yn-1-yloxy)phenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / dichloromethane; 1,4-dioxane / 5 h / 0 - 20 °C

2: triethylamine / dichloromethane / 0 - 20 °C

3: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 9 h / 80 °C

With hydrogenchloride; potassium carbonate; triethylamine; potassium iodide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1313010-11-5
tert-butyl 4-{4-[(Z/E)-(hydroxyimino)methyl]-1,3-thiazol-2-yl}piperidine-1-carboxylate

: 1313009-76-5
2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]-1-(4-{4-[5-(2-chloro-6-(prop-2-yn-1-yloxy)phenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 5 steps

1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.5 h / 50 °C

2: potassium hydrogencarbonate / ethyl acetate; water / 20 °C

3: hydrogenchloride / dichloromethane; 1,4-dioxane / 5 h / 0 - 20 °C

4: triethylamine / dichloromethane / 0 - 20 °C

5: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 9 h / 80 °C

With hydrogenchloride; N-chloro-succinimide; potassium carbonate; potassium hydrogencarbonate; triethylamine; potassium iodide; In 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;