N-(2-methoxyethyl)-9-oxo-9-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)nonanamide

Base Information

Chemical Name:N-(2-methoxyethyl)-9-oxo-9-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)nonanamide
CAS No.:1432445-20-9
Molecular Formula:C₂₃H₃₄F₃N₃O₃
Molecular Weight:457.536
Hs Code.:

Synonyms:N-(2-methoxyethyl)-9-oxo-9-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)nonanamide

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Chemical Property of N-(2-methoxyethyl)-9-oxo-9-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)nonanamide

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Technology Process of N-(2-methoxyethyl)-9-oxo-9-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)nonanamide

There total 4 articles about N-(2-methoxyethyl)-9-oxo-9-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)nonanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1432445-19-6
9-oxo-9-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)nonanoic acid

: 109-85-3
2-methoxyethylamine

: 1432445-20-9
N-(2-methoxyethyl)-9-oxo-9-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)nonanamide

Guidance literature:: 9-oxo-9-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)nonanoic acid; With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h; Inert atmosphere;

2-methoxyethylamine; In N,N-dimethyl-formamide; for 24h; Inert atmosphere;

Reference yield:

: 30459-17-7
1-[4-(trifluoromethyl)phenyl]piperazine

: 1432445-20-9
N-(2-methoxyethyl)-9-oxo-9-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)nonanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

1.2: 16 h / Inert atmosphere

2.1: potassium hydroxide / ethanol / 3 h / Reflux

3.1: benzotriazol-1-ol; triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere; Schlenk technique

3.2: 20 h / 20 °C / Inert atmosphere; Schlenk technique

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; potassium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2020.112416

Reference yield:

: 1432445-32-3
methyl 9-oxo-9-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)nonanoate

: 1432445-20-9
N-(2-methoxyethyl)-9-oxo-9-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)nonanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / ethanol / 3 h / Reflux

2.1: benzotriazol-1-ol; triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere; Schlenk technique

2.2: 20 h / 20 °C / Inert atmosphere; Schlenk technique

With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; potassium hydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2020.112416