N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-3-methylbenzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.02,7]undec-5-en-5-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-N-methylmethanesulfonamide

Base Information

Chemical Name:N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-3-methylbenzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.02,7]undec-5-en-5-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-N-methylmethanesulfonamide
CAS No.:1071517-80-0
Molecular Formula:C₂₇H₂₉FN₄O₆S₂
Molecular Weight:588.681
Hs Code.:

N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-3-methylbenzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.02,7]undec-5-en-5-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-N-methylmethanesulfonamide

Synonyms:N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-3-methylbenzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.02,7]undec-5-en-5-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-N-methylmethanesulfonamide

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Chemical Property of N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-3-methylbenzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.02,7]undec-5-en-5-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-N-methylmethanesulfonamide

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Technology Process of N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-3-methylbenzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.02,7]undec-5-en-5-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-N-methylmethanesulfonamide

There total 14 articles about N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-3-methylbenzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.02,7]undec-5-en-5-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-N-methylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1071517-74-2
N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-3-methylbenzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.02,7]undec-5-en-5-yl]-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}methanesulfonamide

: 74-88-4
methyl iodide

: 1071517-80-0
N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-3-methylbenzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.02,7]undec-5-en-5-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-N-methylmethanesulfonamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 25 ℃; for 18h;

Reference yield:

: 54734-85-9
2-amino-5-nitrobenzenesulfonamide

: 1071517-80-0
N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-3-methylbenzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.02,7]undec-5-en-5-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-N-methylmethanesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / 5%-palladium/activated carbon / ethanol; water / 8 h / 55 °C / Industry scale

2.1: pyridine / dichloromethane / 0 - 23 °C / Industry scale

3.1: tetrahydrofuran / 1 h / 0 - 23 °C / Industry scale

4.1: sodium hydroxide; water / 30 h / 23 °C / Industry scale

4.2: 0 °C / Industry scale

5.1: 4-methyl-morpholine / N,N-dimethyl-formamide / 0.08 h

5.2: 4 h / 25 °C

5.3: 16 h / 50 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 25 °C

With 4-methyl-morpholine; pyridine; water; hydrogen; potassium carbonate; sodium hydroxide; 5%-palladium/activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 96-75-3
2-amino-5-nitro-benzenesulfonic acid

: 1071517-80-0
N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-3-methylbenzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.02,7]undec-5-en-5-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-N-methylmethanesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: trichlorophosphate / sulfolane / 80 - 120 °C

1.2: 10 - 95 °C

1.3: 25 - 80 °C / pH 6 - 8

2.1: hydrogen / 5%-palladium/activated carbon / ethanol; water / 8 h / 55 °C / Industry scale

3.1: pyridine / dichloromethane / 0 - 23 °C / Industry scale

4.1: tetrahydrofuran / 1 h / 0 - 23 °C / Industry scale

5.1: sodium hydroxide; water / 30 h / 23 °C / Industry scale

5.2: 0 °C / Industry scale

6.1: 4-methyl-morpholine / N,N-dimethyl-formamide / 0.08 h

6.2: 4 h / 25 °C

6.3: 16 h / 50 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 25 °C

With 4-methyl-morpholine; pyridine; water; hydrogen; potassium carbonate; sodium hydroxide; trichlorophosphate; 5%-palladium/activated carbon; In tetrahydrofuran; sulfolane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;