3-ethyl 5-methyl 2-(chloromethyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methylpyridine-3,5-dicarboxylate

Base Information

• Chemical Name: 3-ethyl 5-methyl 2-(chloromethyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methylpyridine-3,5-dicarboxylate
• CAS No.: 107812-86-2
• Molecular Formula: C₁₈H₁₉Cl₂NO₄
• Molecular Weight: 384.259
• Mol file: 107812-86-2.mol

Synonyms:3-ethyl 5-methyl 2-(chloromethyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methylpyridine-3,5-dicarboxylate

Chemical Property of 3-ethyl 5-methyl 2-(chloromethyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methylpyridine-3,5-dicarboxylate

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-ethyl 5-methyl 2-(chloromethyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methylpyridine-3,5-dicarboxylate

There total 11 articles about 3-ethyl 5-methyl 2-(chloromethyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methylpyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.7%

ethyl 2-(2-chlorobenzylidene)-4-chloro-3-oxobutanoate (107812-95-3) + methyl 3-aminocrotonate (14205-39-1) → 3-ethyl 5-methyl 2-(chloromethyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methylpyridine-3,5-dicarboxylate (107812-86-2)

Guidance literature:

at 85 ℃; for 3.5h; Ionic liquid;

Reference yield:

2-chloro-benzaldehyde (89-98-5) → 3-ethyl 5-methyl 2-(chloromethyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methylpyridine-3,5-dicarboxylate (107812-86-2)

Guidance literature:

Multi-step reaction with 5 steps

1: methanol / 16 h / Heating

2: NaOH / dioxane / 16 h / Ambient temperature

3: 1) CDI, 2) LiAlH₄ / 1) THF, 0 deg C, 2h, 2) o deg C, 15 min

4: NaBH₄ / methanol / 0.25 h / 0 °C

5: SO₂Cl₂, imidazole / dimethylformamide / Ambient temperature

With 1H-imidazole; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; sulfuryl dichloride; 1,1'-carbonyldiimidazole; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)81539-8

Reference yield:

3-ethyl 5-methyl 4-(2-chlorophenyl)-2-(hydroxymethyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate (79781-21-8) → 3-ethyl 5-methyl 2-(chloromethyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methylpyridine-3,5-dicarboxylate (107812-86-2)

Guidance literature:

With 1H-imidazole; sulfuryl dichloride; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1016/S0040-4020(01)81539-8

upstream raw materials:

3-ethyl 5-methyl 4-(2-chlorophenyl)-2-(hydroxymethyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

4-(2-Chloro-phenyl)-2-formyl-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester

2-carboxy-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine

2-chloro-benzaldehyde

Downstream raw materials:

2-(2-aminoethylthiomethyl)-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine