3-ethyl 5-methyl 4-(2-chlorophenyl)-2-(hydroxymethyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Base Information

Chemical Name:3-ethyl 5-methyl 4-(2-chlorophenyl)-2-(hydroxymethyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
CAS No.:79781-21-8
Molecular Formula:C₁₈H₂₀ClNO₅
Molecular Weight:365.814
Hs Code.:

Synonyms:3-ethyl 5-methyl 4-(2-chlorophenyl)-2-(hydroxymethyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Suppliers and Price of 3-ethyl 5-methyl 4-(2-chlorophenyl)-2-(hydroxymethyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-(2-Chlorophenyl)-1,4-dihydro-2-(hydroxymethyl)-6-methyl-3,5-pyridinedicarboxylicAcid3-Ethyl5-MethylEster
50mg
$ 1320.00

TRC
4-(2-Chlorophenyl)-1,4-dihydro-2-(hydroxymethyl)-6-methyl-3,5-pyridinedicarboxylicAcid3-Ethyl5-MethylEster
25mg
$ 680.00

Total 3 raw suppliers

Chemical Property of 3-ethyl 5-methyl 4-(2-chlorophenyl)-2-(hydroxymethyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Chemical Property:

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

4-(2-Chlorophenyl)-1,4-dihydro-2-(hydroxymethyl)-6-methyl-3,5-pyridinedicarboxylicAcid3-Ethyl5-MethylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-ethyl 5-methyl 4-(2-chlorophenyl)-2-(hydroxymethyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

There total 10 articles about 3-ethyl 5-methyl 4-(2-chlorophenyl)-2-(hydroxymethyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 88150-42-9
2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine

: C₁₈H₁₉ClN₂O₅

: C₁₉H₂₁ClN₂O₄

: C₁₇H₁₈ClNO₅

: 79781-21-8
3-ethyl 5-methyl 4-(2-chlorophenyl)-2-(hydroxymethyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: In water; at 10 ℃; pH=10; Irradiation;
DOI:10.1371/journal.pone.0109206

Reference yield:

: 79781-18-3
4-(2-Chloro-phenyl)-2-formyl-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester

: 79781-21-8
3-ethyl 5-methyl 4-(2-chlorophenyl)-2-(hydroxymethyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 ℃; for 0.25h; Yield given;
DOI:10.1016/S0040-4020(01)81539-8

Reference yield:

: 129207-93-8
2-carboxy-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine

: 79781-21-8
3-ethyl 5-methyl 4-(2-chlorophenyl)-2-(hydroxymethyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1) CDI, 2) LiAlH₄ / 1) THF, 0 deg C, 2h, 2) o deg C, 15 min

2: NaBH₄ / methanol / 0.25 h / 0 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; 1,1'-carbonyldiimidazole; In methanol;
DOI:10.1016/S0040-4020(01)81539-8