methyl (4R,5R)-trans-7-(2,2-dimethyl-4-(phenylsulfonyl)aminomethyl-1,3-dioxolan-5-yl)-5(Z)-heptanoate

Base Information

Chemical Name:methyl (4R,5R)-trans-7-(2,2-dimethyl-4-(phenylsulfonyl)aminomethyl-1,3-dioxolan-5-yl)-5(Z)-heptanoate
CAS No.:169871-44-7
Molecular Formula:C₂₀H₂₉NO₆S
Molecular Weight:411.519
Hs Code.:

Synonyms:methyl (4R,5R)-trans-7-(2,2-dimethyl-4-(phenylsulfonyl)aminomethyl-1,3-dioxolan-5-yl)-5(Z)-heptanoate

Suppliers and Price of methyl (4R,5R)-trans-7-(2,2-dimethyl-4-(phenylsulfonyl)aminomethyl-1,3-dioxolan-5-yl)-5(Z)-heptanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl (4R,5R)-trans-7-(2,2-dimethyl-4-(phenylsulfonyl)aminomethyl-1,3-dioxolan-5-yl)-5(Z)-heptanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl (4R,5R)-trans-7-(2,2-dimethyl-4-(phenylsulfonyl)aminomethyl-1,3-dioxolan-5-yl)-5(Z)-heptanoate

There total 12 articles about methyl (4R,5R)-trans-7-(2,2-dimethyl-4-(phenylsulfonyl)aminomethyl-1,3-dioxolan-5-yl)-5(Z)-heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 98-09-9
benzenesulfonyl chloride

: 169871-43-6
methyl (4R,5R)-trans-7-(2,2-dimethyl-4-aminomethyl-1,3-dioxolan-5-yl)-5(Z)-heptanoate

: 169871-44-7
methyl (4R,5R)-trans-7-(2,2-dimethyl-4-(phenylsulfonyl)aminomethyl-1,3-dioxolan-5-yl)-5(Z)-heptanoate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 3h;
DOI:10.1016/0223-5234(96)88240-7

Reference yield:

: 73346-74-4
(4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-dimethanol

: 169871-44-7
methyl (4R,5R)-trans-7-(2,2-dimethyl-4-(phenylsulfonyl)aminomethyl-1,3-dioxolan-5-yl)-5(Z)-heptanoate

Guidance literature:: Multi-step reaction with 12 steps

1: 1.) NaH / 1.) THF, 45 min, RT, 2.) THF, 45 min

2: 85 percent / oxalyl chloride, DMSO / CH₂Cl₂ / 0.25 h / -70 °C

3: 1.) nBuLi / 1.) THF, hexane, 30 min, 2.) THF, hexane, a) -25 deg C, 30 min, b) 1 h, RT

4: 1.) 9-BBN, 2.) aq. H₂O₂, NaOH / 1.) THF, RT, 1 h, 2.) EtOH, 15 min

5: 78 percent / oxalyl chloride, DMSO / CH₂Cl₂ / 0.25 h / -70 °C

6: 1.) nBuLi / 1.) THF, hexane, RT, 1 h, 2.) THF, hexane, 1 h

7: methanol; diethyl ether / 0.17 h / Ambient temperature

8: 73 percent / Bu₄NF / tetrahydrofuran / 2 h / Ambient temperature

9: 96 percent / pyridine / 1 h / Ambient temperature

10: dimethylsulfoxide / 5 h / 90 - 100 °C

11: 59 percent / NH₂NH₂ / CH₂Cl₂; ethanol / 24 h / Ambient temperature

12: 40 percent / Et₃N / CH₂Cl₂ / 3 h / 0 °C

With pyridine; sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; n-butyllithium; oxalyl dichloride; tetrabutyl ammonium fluoride; dihydrogen peroxide; sodium hydride; dimethyl sulfoxide; triethylamine; hydrazine; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/0223-5234(96)88240-7

Reference yield:

: 169871-39-0
(4R,5R)-trans-2,2-dimethyl-4-tert-butyldiphenylsiloxymethyl-5-(2-hydroxylethyl)-1,3-dioxolane

: 169871-44-7
methyl (4R,5R)-trans-7-(2,2-dimethyl-4-(phenylsulfonyl)aminomethyl-1,3-dioxolan-5-yl)-5(Z)-heptanoate

Guidance literature:: Multi-step reaction with 8 steps

1: 78 percent / oxalyl chloride, DMSO / CH₂Cl₂ / 0.25 h / -70 °C

2: 1.) nBuLi / 1.) THF, hexane, RT, 1 h, 2.) THF, hexane, 1 h

3: methanol; diethyl ether / 0.17 h / Ambient temperature

4: 73 percent / Bu₄NF / tetrahydrofuran / 2 h / Ambient temperature

5: 96 percent / pyridine / 1 h / Ambient temperature

6: dimethylsulfoxide / 5 h / 90 - 100 °C

7: 59 percent / NH₂NH₂ / CH₂Cl₂; ethanol / 24 h / Ambient temperature

8: 40 percent / Et₃N / CH₂Cl₂ / 3 h / 0 °C

With pyridine; n-butyllithium; oxalyl dichloride; tetrabutyl ammonium fluoride; dimethyl sulfoxide; triethylamine; hydrazine; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/0223-5234(96)88240-7