N-cyclopropyl-4-methyl-3-{2-oxo-3-[(2-{2-[2-(pyrrolidin-1-yl)ethoxy]phenyl}propan-2-yl)amino]pyrazin-1(2H)-yl}benzamide

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Chemical Name:N-cyclopropyl-4-methyl-3-{2-oxo-3-[(2-{2-[2-(pyrrolidin-1-yl)ethoxy]phenyl}propan-2-yl)amino]pyrazin-1(2H)-yl}benzamide
CAS No.:1095003-50-1
Molecular Formula:C₃₀H₃₇N₅O₃
Molecular Weight:515.655
Hs Code.:

Synonyms:N-cyclopropyl-4-methyl-3-{2-oxo-3-[(2-{2-[2-(pyrrolidin-1-yl)ethoxy]phenyl}propan-2-yl)amino]pyrazin-1(2H)-yl}benzamide

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Chemical Property of N-cyclopropyl-4-methyl-3-{2-oxo-3-[(2-{2-[2-(pyrrolidin-1-yl)ethoxy]phenyl}propan-2-yl)amino]pyrazin-1(2H)-yl}benzamide

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Technology Process of N-cyclopropyl-4-methyl-3-{2-oxo-3-[(2-{2-[2-(pyrrolidin-1-yl)ethoxy]phenyl}propan-2-yl)amino]pyrazin-1(2H)-yl}benzamide

There total 8 articles about N-cyclopropyl-4-methyl-3-{2-oxo-3-[(2-{2-[2-(pyrrolidin-1-yl)ethoxy]phenyl}propan-2-yl)amino]pyrazin-1(2H)-yl}benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1095003-49-8
N-cyclopropyl-3-(3-(2-(2-hydroxyphenyl)propan-2-ylamino)-2-oxopyrazin-1(2H)-yl)-4-methylbenzamide

: 7250-67-1
1-(2-chloroethyl)pyrrolidine hydrochloride

: 1095003-50-1
N-cyclopropyl-4-methyl-3-{2-oxo-3-[(2-{2-[2-(pyrrolidin-1-yl)ethoxy]phenyl}propan-2-yl)amino]pyrazin-1(2H)-yl}benzamide

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 90 - 100 ℃; for 20h;
DOI:10.1016/j.bmcl.2020.127412

Reference yield:

: 1095005-58-5
methyl 3-[(cyanomethyl)amino]-4-methylbenzoate

: 1095003-50-1
N-cyclopropyl-4-methyl-3-{2-oxo-3-[(2-{2-[2-(pyrrolidin-1-yl)ethoxy]phenyl}propan-2-yl)amino]pyrazin-1(2H)-yl}benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1,2-dichloro-benzene / 4 h / 100 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1.67 h / 120 °C / Microwave irradiation

3: cyclopentylmagnesium bromide / tetrahydrofuran; diethyl ether / 0.5 h / 20 °C

4: ammonium formate / palladium 10% on activated carbon / ethanol / 2 h / 60 - 100 °C / Microwave irradiation

5: caesium carbonate / N,N-dimethyl-formamide / 34 h / 80 - 100 °C

With ammonium formate; caesium carbonate; N-ethyl-N,N-diisopropylamine; cyclopentylmagnesium bromide; palladium 10% on activated carbon; In tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide; 1,2-dichloro-benzene;

Reference yield:

: 1095005-59-6
methyl 3-(3,5-dibromo-2-oxopyrazin-1(2H)-yl)-4-methylbenzoate

: 1095003-50-1
N-cyclopropyl-4-methyl-3-{2-oxo-3-[(2-{2-[2-(pyrrolidin-1-yl)ethoxy]phenyl}propan-2-yl)amino]pyrazin-1(2H)-yl}benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1.67 h / 120 °C / Microwave irradiation

2: cyclopentylmagnesium bromide / tetrahydrofuran; diethyl ether / 0.5 h / 20 °C

3: ammonium formate / palladium 10% on activated carbon / ethanol / 2 h / 60 - 100 °C / Microwave irradiation

4: caesium carbonate / N,N-dimethyl-formamide / 34 h / 80 - 100 °C

With ammonium formate; caesium carbonate; N-ethyl-N,N-diisopropylamine; cyclopentylmagnesium bromide; palladium 10% on activated carbon; In tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide;