O-(N₄,2',3'-O,O-tribenzoylcytidin-5'-yl)-O-{N₂-isobutyryl-2'-O-methyl-5'-O-[bis-(2-cyano-1,1-dimethylethyl)thionophosphoryl]guanosin-3'-yl} hydrogenophosphonate diester

Base Information

• Chemical Name: O-(N₄,2',3'-O,O-tribenzoylcytidin-5'-yl)-O-{N₂-isobutyryl-2'-O-methyl-5'-O-[bis-(2-cyano-1,1-dimethylethyl)thionophosphoryl]guanosin-3'-yl} hydrogenophosphonate diester
• CAS No.: 1058150-83-6
• Molecular Formula: C₅₅H₆₀N₁₀O₁₇P₂S
• Molecular Weight: 1227.15

Synonyms:O-(N₄,2',3'-O,O-tribenzoylcytidin-5'-yl)-O-{N₂-isobutyryl-2'-O-methyl-5'-O-[bis-(2-cyano-1,1-dimethylethyl)thionophosphoryl]guanosin-3'-yl} hydrogenophosphonate diester

Chemical Property of O-(N₄,2',3'-O,O-tribenzoylcytidin-5'-yl)-O-{N₂-isobutyryl-2'-O-methyl-5'-O-[bis-(2-cyano-1,1-dimethylethyl)thionophosphoryl]guanosin-3'-yl} hydrogenophosphonate diester

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Technology Process of O-(N₄,2',3'-O,O-tribenzoylcytidin-5'-yl)-O-{N₂-isobutyryl-2'-O-methyl-5'-O-[bis-(2-cyano-1,1-dimethylethyl)thionophosphoryl]guanosin-3'-yl} hydrogenophosphonate diester

There total 1 articles about O-(N₄,2',3'-O,O-tribenzoylcytidin-5'-yl)-O-{N₂-isobutyryl-2'-O-methyl-5'-O-[bis-(2-cyano-1,1-dimethylethyl)thionophosphoryl]guanosin-3'-yl} hydrogenophosphonate diester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

thiophosphoric acid O,O'-bis-(2-cyano-1,1-dimethyl-ethyl) ester O''-[3-hydroxy-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-methoxy-tetrahydro-furan-2-ylmethyl] ester + N4,2',3'-O,O-tribenzoylcytidin-5'-yl hydrogenophosphonate, triethylammonium salt (1058150-71-2) → O-(N4,2',3'-O,O-tribenzoylcytidin-5'-yl)-O-{N2-isobutyryl-2'-O-methyl-5'-O-[bis-(2-cyano-1,1-dimethylethyl)thionophosphoryl]guanosin-3'-yl} hydrogenophosphonate diester (1058150-83-6)

Guidance literature:

With pyridine; PS acyl chloride resin; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/jm800617c

Reference yield:

O-(N4,2',3'-O,O-tribenzoylcytidin-5'-yl)-O-{N2-isobutyryl-2'-O-methyl-5'-O-[bis-(2-cyano-1,1-dimethylethyl)thionophosphoryl]guanosin-3'-yl} hydrogenophosphonate diester (1058150-83-6) + methyl 6-aminocaproate hydrochloride (1926-80-3) → C62H73N11O19P2S

Guidance literature:

With pyridine; tetrachloromethane; triethylamine; at 20 ℃; for 1h;

DOI:10.1021/jm800617c

Reference yield:

O-(N4,2',3'-O,O-tribenzoylcytidin-5'-yl)-O-{N2-isobutyryl-2'-O-methyl-5'-O-[bis-(2-cyano-1,1-dimethylethyl)thionophosphoryl]guanosin-3'-yl} hydrogenophosphonate diester (1058150-83-6) + 2-methoxyethylamine (109-85-3) → C58H67N11O18P2S

Guidance literature:

With pyridine; tetrachloromethane; at 20 ℃; for 1h;

DOI:10.1021/jm800617c

upstream raw materials:

N₄,2',3'-O,O-tribenzoylcytidin-5'-yl hydrogenophosphonate, triethylammonium salt

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