5-(3-aminopropyl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)furo[2,3-b]pyridine-3-carboxamide

Base Information

Chemical Name:5-(3-aminopropyl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)furo[2,3-b]pyridine-3-carboxamide
CAS No.:1345175-06-5
Molecular Formula:C₂₀H₂₃FN₄O₄S
Molecular Weight:434.491
Hs Code.:

Synonyms:5-(3-aminopropyl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)furo[2,3-b]pyridine-3-carboxamide

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Chemical Property of 5-(3-aminopropyl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)furo[2,3-b]pyridine-3-carboxamide

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Technology Process of 5-(3-aminopropyl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)furo[2,3-b]pyridine-3-carboxamide

There total 4 articles about 5-(3-aminopropyl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)furo[2,3-b]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1345175-02-1
(E)-5-(2-cyanovinyl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)furo[2,3-b]pyridine-3-carboxamide

: 1345175-04-3
5-(2-cyanoethyl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)furo[2,3-b]pyridine-3-carboxamide

: 1345175-06-5
5-(3-aminopropyl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)furo[2,3-b]pyridine-3-carboxamide

Guidance literature:: With hydrogen; 10% palladium hydroxide on charcoal; In tetrahydrofuran; methanol;

Reference yield:

: 1345173-98-9
6-amino-2-(4-fluoro-phenyl)-5-iodo-furo[2,3-b]pyridine-3-carboxylic acid

: 1345175-04-3
5-(2-cyanoethyl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)furo[2,3-b]pyridine-3-carboxamide

: 1345175-06-5
5-(3-aminopropyl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)furo[2,3-b]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 16 h / 0 - 5 °C

1.2: 0 °C

2.1: potassium carbonate / acetone / 24 h / 60 °C

3.1: triethylamine / palladium diacetate / N,N-dimethyl-formamide / 0.67 h / 120 °C / Microwave irradiation

4.1: hydrogen / 10% palladium hydroxide on charcoal / tetrahydrofuran; methanol

With hydrogen; potassium carbonate; triethylamine; 10% palladium hydroxide on charcoal; palladium diacetate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1345174-00-6
2-(4-fluoro-phenyl)-5-iodo-6-methanesulfonylamino-furo[2,3-b]pyridine-3-carboxylic acid methylamide

: 1345175-04-3
5-(2-cyanoethyl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)furo[2,3-b]pyridine-3-carboxamide

: 1345175-06-5
5-(3-aminopropyl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)furo[2,3-b]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 24 h / 60 °C

2: triethylamine / palladium diacetate / N,N-dimethyl-formamide / 0.67 h / 120 °C / Microwave irradiation

3: hydrogen / 10% palladium hydroxide on charcoal / tetrahydrofuran; methanol

With hydrogen; potassium carbonate; triethylamine; 10% palladium hydroxide on charcoal; palladium diacetate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetone;