4-{2-Benzyloxy-5-[(E)-2-(3-methoxy-phenyl)-vinyl]-phenoxy}-benzaldehyde

Base Information

• Chemical Name: 4-{2-Benzyloxy-5-[(E)-2-(3-methoxy-phenyl)-vinyl]-phenoxy}-benzaldehyde
• CAS No.: 135203-59-7
• Molecular Formula: C₂₉H₂₄O₄
• Molecular Weight: 436.507
• Mol file: 135203-59-7.mol

Synonyms:4-{2-Benzyloxy-5-[(E)-2-(3-methoxy-phenyl)-vinyl]-phenoxy}-benzaldehyde

Chemical Property of 4-{2-Benzyloxy-5-[(E)-2-(3-methoxy-phenyl)-vinyl]-phenoxy}-benzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-{2-Benzyloxy-5-[(E)-2-(3-methoxy-phenyl)-vinyl]-phenoxy}-benzaldehyde

There total 5 articles about 4-{2-Benzyloxy-5-[(E)-2-(3-methoxy-phenyl)-vinyl]-phenoxy}-benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.1%

(4-{2-Benzyloxy-5-[(E)-2-(3-methoxy-phenyl)-vinyl]-phenoxy}-phenyl)-methanol (135203-58-6) → 4-{2-Benzyloxy-5-[(E)-2-(3-methoxy-phenyl)-vinyl]-phenoxy}-benzaldehyde (135203-59-7)

Guidance literature:

With dipyridinium dichromate; In dichloromethane; for 12h;

DOI:10.1016/0031-9422(91)84201-3

Reference yield:

Ethyl 4-bromobenzoate (5798-75-4) → 4-{2-Benzyloxy-5-[(E)-2-(3-methoxy-phenyl)-vinyl]-phenoxy}-benzaldehyde (135203-59-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 81.3 percent / K₂CO₃, CuO / pyridine / 24 h / Heating

2: 1) KOt-Bu / 1) DMF, 0-5 deg C, 15 min, 2) DMF, 4h, r. t.

3: 99.1 percent / LiAlH₄ / diethyl ether / 4 h / Ambient temperature

4: 95.1 percent / pyridinium dichromate / CH₂Cl₂ / 12 h

With lithium aluminium tetrahydride; dipyridinium dichromate; potassium tert-butylate; potassium carbonate; copper(II) oxide; In pyridine; diethyl ether; dichloromethane;

DOI:10.1016/0031-9422(91)84201-3

Reference yield:

4-benzyloxy-3-hydroxy-benzaldehyde (4049-39-2) → 4-{2-Benzyloxy-5-[(E)-2-(3-methoxy-phenyl)-vinyl]-phenoxy}-benzaldehyde (135203-59-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 81.3 percent / K₂CO₃, CuO / pyridine / 24 h / Heating

2: 1) KOt-Bu / 1) DMF, 0-5 deg C, 15 min, 2) DMF, 4h, r. t.

3: 99.1 percent / LiAlH₄ / diethyl ether / 4 h / Ambient temperature

4: 95.1 percent / pyridinium dichromate / CH₂Cl₂ / 12 h

With lithium aluminium tetrahydride; dipyridinium dichromate; potassium tert-butylate; potassium carbonate; copper(II) oxide; In pyridine; diethyl ether; dichloromethane;

DOI:10.1016/0031-9422(91)84201-3

upstream raw materials:

(4-{2-Benzyloxy-5-[(E)-2-(3-methoxy-phenyl)-vinyl]-phenoxy}-phenyl)-methanol

Ethyl 4-bromobenzoate

4-benzyloxy-3-hydroxy-benzaldehyde

ethyl 4-(2-benzyloxy-5-formylphenoxy)benzoate

Downstream raw materials:

Acetic acid 2-{4-[2-(2,5-diacetoxy-phenyl)-ethyl]-phenoxy}-4-[2-(3-methoxy-phenyl)-ethyl]-phenyl ester

Acetic acid 2-{4-[2-(3-acetoxy-phenyl)-ethyl]-phenoxy}-4-[2-(3-methoxy-phenyl)-ethyl]-phenyl ester

perrottetin E-11,1'-diethyl-11'-methyl ether

14-hydroxyperottetin E-11'-methyl ether