perrottetin E-11,1'-diethyl-11'-methyl ether

Base Information

• Chemical Name: perrottetin E-11,1'-diethyl-11'-methyl ether
• CAS No.: 135203-52-0
• Molecular Formula: C₃₃H₃₆O₄
• Molecular Weight: 496.646
• Mol file: 135203-52-0.mol

Synonyms:perrottetin E-11,1'-diethyl-11'-methyl ether

Chemical Property of perrottetin E-11,1'-diethyl-11'-methyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of perrottetin E-11,1'-diethyl-11'-methyl ether

There total 8 articles about perrottetin E-11,1'-diethyl-11'-methyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.7%

perottetin E-11'-methyl ether (135203-46-2) + ethyl iodide (75-03-6) → perrottetin E-11,1'-diethyl-11'-methyl ether (135203-52-0)

Guidance literature:

With potassium carbonate; In acetone; Heating;

DOI:10.1016/0031-9422(91)84201-3

Reference yield:

Ethyl 4-bromobenzoate (5798-75-4) → perrottetin E-11,1'-diethyl-11'-methyl ether (135203-52-0)

Guidance literature:

Multi-step reaction with 7 steps

1: 81.3 percent / K₂CO₃, CuO / pyridine / 24 h / Heating

2: 1) KOt-Bu / 1) DMF, 0-5 deg C, 15 min, 2) DMF, 4h, r. t.

3: 99.1 percent / LiAlH₄ / diethyl ether / 4 h / Ambient temperature

4: 95.1 percent / pyridinium dichromate / CH₂Cl₂ / 12 h

5: 1) KOt-Bu / 1) DMF, 0-5 deg C, 15 min, 2) DMF, r. t.

6: 80.7 percent / H₂ / 20percent Pd-C / ethyl acetate / Ambient temperature

7: 91.7 percent / K₂CO₃ / acetone / Heating

With lithium aluminium tetrahydride; dipyridinium dichromate; potassium tert-butylate; hydrogen; potassium carbonate; copper(II) oxide; palladium on activated charcoal; In pyridine; diethyl ether; dichloromethane; ethyl acetate; acetone;

DOI:10.1016/0031-9422(91)84201-3

Reference yield:

4-benzyloxy-3-hydroxy-benzaldehyde (4049-39-2) → perrottetin E-11,1'-diethyl-11'-methyl ether (135203-52-0)

Guidance literature:

Multi-step reaction with 7 steps

1: 81.3 percent / K₂CO₃, CuO / pyridine / 24 h / Heating

2: 1) KOt-Bu / 1) DMF, 0-5 deg C, 15 min, 2) DMF, 4h, r. t.

3: 99.1 percent / LiAlH₄ / diethyl ether / 4 h / Ambient temperature

4: 95.1 percent / pyridinium dichromate / CH₂Cl₂ / 12 h

5: 1) KOt-Bu / 1) DMF, 0-5 deg C, 15 min, 2) DMF, r. t.

6: 80.7 percent / H₂ / 20percent Pd-C / ethyl acetate / Ambient temperature

7: 91.7 percent / K₂CO₃ / acetone / Heating

With lithium aluminium tetrahydride; dipyridinium dichromate; potassium tert-butylate; hydrogen; potassium carbonate; copper(II) oxide; palladium on activated charcoal; In pyridine; diethyl ether; dichloromethane; ethyl acetate; acetone;

DOI:10.1016/0031-9422(91)84201-3

upstream raw materials:

perottetin E-11'-methyl ether

ethyl iodide

Ethyl 4-bromobenzoate

4-benzyloxy-3-hydroxy-benzaldehyde

Downstream raw materials:

3-ethoxy-4'-hydroxydihydrostilbene

4-ethoxy-3'-methoxydihydrostilbene

Refernces