methyl 4-(1-(2-chloro-6-cyclohexylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

Base Information

Chemical Name:methyl 4-(1-(2-chloro-6-cyclohexylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate
CAS No.:1562995-94-1
Molecular Formula:C₂₇H₂₃ClFN₃O₃
Molecular Weight:491.949
Hs Code.:

Synonyms:methyl 4-(1-(2-chloro-6-cyclohexylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

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Chemical Property of methyl 4-(1-(2-chloro-6-cyclohexylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

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Technology Process of methyl 4-(1-(2-chloro-6-cyclohexylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

There total 9 articles about methyl 4-(1-(2-chloro-6-cyclohexylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1562194-90-4
methyl 3-fluoro-4-(1H-pyrazolo[4,3-b]pyridin-3-yl)benzoate

: 1562995-60-1
2-chloro-6-cyclohexylbenzoyl chloride

: 1562995-94-1
methyl 4-(1-(2-chloro-6-cyclohexylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

Guidance literature:: methyl 3-fluoro-4-(1H-pyrazolo[4,3-b]pyridin-3-yl)benzoate; With sodium hydride; In tetrahydrofuran; at 0 - 15 ℃; for 0.5h;

2-chloro-6-cyclohexylbenzoyl chloride; In tetrahydrofuran; at 0 - 15 ℃; for 2.5h;

Reference yield:

: 1562995-59-8
2-chloro-6-cyclohexylbenzoic acid

: 1562995-94-1
methyl 4-(1-(2-chloro-6-cyclohexylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / 24 h / Reflux; Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 15 °C

2.2: 2.5 h / 0 - 15 °C

With thionyl chloride; sodium hydride; In tetrahydrofuran;

Reference yield:

: 633328-40-2
3-iodo-1H-pyrazolo[4,3-b]pyridine

: 1562995-94-1
methyl 4-(1-(2-chloro-6-cyclohexylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / tetrahydrofuran / 6 h / Reflux

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / toluene; ethanol / 6 h / 120 °C / Inert atmosphere

3.1: hydrogenchloride / methanol / 14 h / Reflux

4.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 15 °C

4.2: 2.5 h / 0 - 15 °C

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydride; sodium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; ethanol; toluene; 2.1: |Suzuki Coupling;