2-{benzyl-[2-(1H-indol-3-yl)-1-methoxycarbonyl-ethyl]-carbamoyl}-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

Base Information

Chemical Name:2-{benzyl-[2-(1H-indol-3-yl)-1-methoxycarbonyl-ethyl]-carbamoyl}-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester
CAS No.:274677-64-4
Molecular Formula:C₃₉H₃₇N₃O₅
Molecular Weight:627.74
Hs Code.:

2-{benzyl-[2-(1<i>H</i>-indol-3-yl)-1-methoxycarbonyl-ethyl]-carbamoyl}-pyrrolidine-1-carboxylic acid 9<i>H</i>-fluoren-9-ylmethyl ester

Synonyms:2-{benzyl-[2-(1H-indol-3-yl)-1-methoxycarbonyl-ethyl]-carbamoyl}-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

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Chemical Property of 2-{benzyl-[2-(1H-indol-3-yl)-1-methoxycarbonyl-ethyl]-carbamoyl}-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

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Technology Process of 2-{benzyl-[2-(1H-indol-3-yl)-1-methoxycarbonyl-ethyl]-carbamoyl}-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

There total 4 articles about 2-{benzyl-[2-(1H-indol-3-yl)-1-methoxycarbonyl-ethyl]-carbamoyl}-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 103321-52-4
(S)-N-(fluoren-9-ylmethoxycarbonyl)prolyl chloride

: 63229-68-5
methyl N-benzyl-L-tryptophanate

: 274677-64-4
2-{benzyl-[2-(1H-indol-3-yl)-1-methoxycarbonyl-ethyl]-carbamoyl}-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: With sodium carbonate; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jm9905662

Reference yield:

: 19779-75-0,67628-15-3
N_b-benzylidene-L-tryptophan methyl ester

: 274677-64-4
2-{benzyl-[2-(1H-indol-3-yl)-1-methoxycarbonyl-ethyl]-carbamoyl}-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / NaBH(OAc)3 / CH₂Cl₂ / 44 h / 20 °C

2: 100 percent / aq. Na₂CO₃ / CH₂Cl₂ / 1 h / 20 °C

With sodium tris(acetoxy)borohydride; sodium carbonate; In dichloromethane; 1: Reduction / 2: Acylation;
DOI:10.1021/jm9905662

Reference yield:

: 100-52-7
benzaldehyde

: 274677-64-4
2-{benzyl-[2-(1H-indol-3-yl)-1-methoxycarbonyl-ethyl]-carbamoyl}-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: HC(OMe)3 / CH₂Cl₂ / 18.5 h

2: 100 percent / NaBH(OAc)3 / CH₂Cl₂ / 44 h / 20 °C

3: 100 percent / aq. Na₂CO₃ / CH₂Cl₂ / 1 h / 20 °C

With sodium tris(acetoxy)borohydride; sodium carbonate; trimethyl orthoformate; In dichloromethane; 1: Condensation / 2: Reduction / 3: Acylation;
DOI:10.1021/jm9905662