3-(4-((6-hydroxy-2-(4-hydroxyphenyl)-benzo-[b]thiophen-3-yl)oxy)phenyl)propanoic acid

Base Information

• Chemical Name: 3-(4-((6-hydroxy-2-(4-hydroxyphenyl)-benzo-[b]thiophen-3-yl)oxy)phenyl)propanoic acid
• CAS No.: 1622307-13-4
• Molecular Formula: C₂₃H₁₈O₅S
• Molecular Weight: 406.459

Synonyms:3-(4-((6-hydroxy-2-(4-hydroxyphenyl)-benzo-[b]thiophen-3-yl)oxy)phenyl)propanoic acid

Chemical Property of 3-(4-((6-hydroxy-2-(4-hydroxyphenyl)-benzo-[b]thiophen-3-yl)oxy)phenyl)propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-((6-hydroxy-2-(4-hydroxyphenyl)-benzo-[b]thiophen-3-yl)oxy)phenyl)propanoic acid

There total 7 articles about 3-(4-((6-hydroxy-2-(4-hydroxyphenyl)-benzo-[b]thiophen-3-yl)oxy)phenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

tert-butyl 3-(4-((6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl)oxy)phenyl)propanoate (1622308-76-2) → 3-(4-((6-hydroxy-2-(4-hydroxyphenyl)-benzo-[b]thiophen-3-yl)oxy)phenyl)propanoic acid (1622307-13-4)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

3-(4-bromophenoxy)-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene (1622308-87-5) → 3-(4-((6-hydroxy-2-(4-hydroxyphenyl)-benzo-[b]thiophen-3-yl)oxy)phenyl)propanoic acid (1622307-13-4)

Guidance literature:

Multi-step reaction with 3 steps

1: bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 1 h / 120 °C / Microwave irradiation

2: hydrogen; palladium 10% on activated carbon / dichloromethane; methanol / 12 h / 20 °C

3: boron tribromide / dichloromethane / 1 h / 0 °C

With bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; hydrogen; boron tribromide; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

2-(4'-methoxyphenyl)-6-methoxybenzothiophene (63675-74-1) → 3-(4-((6-hydroxy-2-(4-hydroxyphenyl)-benzo-[b]thiophen-3-yl)oxy)phenyl)propanoic acid (1622307-13-4)

Guidance literature:

Multi-step reaction with 7 steps

1.1: N-Bromosuccinimide / tetrahydrofuran / 3 h / 0 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 0.17 h / 20 °C

2.2: 1.5 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 20 °C

3.2: 18 h / 80 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

5.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 1 h / 120 °C / Microwave irradiation

6.1: hydrogen; palladium 10% on activated carbon / dichloromethane; methanol / 12 h / 20 °C

7.1: boron tribromide / dichloromethane / 1 h / 0 °C

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; boron tribromide; sodium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

3-(4-bromophenoxy)-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene 1-oxide

3-(4-bromophenoxy)-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

3-bromo-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1622307-13-4 3-(4-((6-hydroxy-2-(4-hydroxyphenyl)-benzo-[b]thiophen-3-yl)oxy)phenyl)propanoic acid

Send

Send

Metric Ton KG G Pound L ML

Send

Send