2-((2R,3R)-1-Acetyl-2-isopropoxy-5-oxo-pyrrolidin-3-yl)-2-benzyl-malonic acid dimethyl ester

Base Information

Chemical Name:2-((2R,3R)-1-Acetyl-2-isopropoxy-5-oxo-pyrrolidin-3-yl)-2-benzyl-malonic acid dimethyl ester
CAS No.:201014-18-8
Molecular Formula:C₂₁H₂₇NO₇
Molecular Weight:405.448
Hs Code.:

Synonyms:2-((2R,3R)-1-Acetyl-2-isopropoxy-5-oxo-pyrrolidin-3-yl)-2-benzyl-malonic acid dimethyl ester

Suppliers and Price of 2-((2R,3R)-1-Acetyl-2-isopropoxy-5-oxo-pyrrolidin-3-yl)-2-benzyl-malonic acid dimethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-((2R,3R)-1-Acetyl-2-isopropoxy-5-oxo-pyrrolidin-3-yl)-2-benzyl-malonic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-((2R,3R)-1-Acetyl-2-isopropoxy-5-oxo-pyrrolidin-3-yl)-2-benzyl-malonic acid dimethyl ester

There total 3 articles about 2-((2R,3R)-1-Acetyl-2-isopropoxy-5-oxo-pyrrolidin-3-yl)-2-benzyl-malonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 100-44-7
benzyl chloride

: 201014-14-4
2-((2R,3R)-1-Acetyl-2-isopropoxy-5-oxo-pyrrolidin-3-yl)-malonic acid dimethyl ester

: 201014-18-8
2-((2R,3R)-1-Acetyl-2-isopropoxy-5-oxo-pyrrolidin-3-yl)-2-benzyl-malonic acid dimethyl ester

Guidance literature:: With sodium hydride; lithium iodide; In N,N-dimethyl-formamide; for 18h; Ambient temperature;
DOI:10.1021/jo971854d

Reference yield:

: 138259-70-8
(R)-1-acetyl-5-isopropoxy-3-pyrrolin-2-one

: 201014-18-8
2-((2R,3R)-1-Acetyl-2-isopropoxy-5-oxo-pyrrolidin-3-yl)-2-benzyl-malonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / triethylamine / dimethylformamide

2: 76 percent / NaH, LiI / dimethylformamide / 18 h / Ambient temperature

With sodium hydride; triethylamine; lithium iodide; In N,N-dimethyl-formamide;
DOI:10.1021/jo971854d

Reference yield:

: 108-59-8
malonic acid dimethyl ester

: 201014-18-8
2-((2R,3R)-1-Acetyl-2-isopropoxy-5-oxo-pyrrolidin-3-yl)-2-benzyl-malonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / triethylamine / dimethylformamide

2: 76 percent / NaH, LiI / dimethylformamide / 18 h / Ambient temperature

With sodium hydride; triethylamine; lithium iodide; In N,N-dimethyl-formamide;
DOI:10.1021/jo971854d