5-{[4-hydroxy-7-(4-methoxybenzylamino)isoquinoline-3-carbonyl]amino}pentanoic acid

Base Information

Chemical Name:5-{[4-hydroxy-7-(4-methoxybenzylamino)isoquinoline-3-carbonyl]amino}pentanoic acid
CAS No.:1455089-60-7
Molecular Formula:C₂₃H₂₅N₃O₅
Molecular Weight:423.469
Hs Code.:

Synonyms:5-{[4-hydroxy-7-(4-methoxybenzylamino)isoquinoline-3-carbonyl]amino}pentanoic acid

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Chemical Property of 5-{[4-hydroxy-7-(4-methoxybenzylamino)isoquinoline-3-carbonyl]amino}pentanoic acid

Chemical Property:

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Technology Process of 5-{[4-hydroxy-7-(4-methoxybenzylamino)isoquinoline-3-carbonyl]amino}pentanoic acid

There total 4 articles about 5-{[4-hydroxy-7-(4-methoxybenzylamino)isoquinoline-3-carbonyl]amino}pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1455094-02-6
methyl 4-hydroxy-7-(4-methoxybenzylamino)isoquinoline-3-carboxylate

: 660-88-8
5-aminopentanoic acid

: 1455089-60-7
5-{[4-hydroxy-7-(4-methoxybenzylamino)isoquinoline-3-carbonyl]amino}pentanoic acid

Guidance literature:: With sodium methylate; In methanol; for 20h; Reflux;

Reference yield:

: 7-bromo-4-hydroxyisoquinoline-3-carboxylic acid methyl ester

: 1455089-60-7
5-{[4-hydroxy-7-(4-methoxybenzylamino)isoquinoline-3-carbonyl]amino}pentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 16 h / 60 °C

2: potassium carbonate; L-proline; copper(l) iodide / dimethyl sulfoxide / 24 h / 80 °C / Inert atmosphere

3: palladium on activated carbon; hydrogen / ethanol; ethyl acetate / 16 h / 20 °C

4: sodium methylate / methanol / 20 h / Reflux

With copper(l) iodide; palladium on activated carbon; hydrogen; sodium methylate; potassium carbonate; L-proline; potassium iodide; In methanol; ethanol; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1455093-98-7
methyl 4-(benzyloxy)-7-bromoisoquinoline-3-carboxylate

: 1455089-60-7
5-{[4-hydroxy-7-(4-methoxybenzylamino)isoquinoline-3-carbonyl]amino}pentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; L-proline; copper(l) iodide / dimethyl sulfoxide / 24 h / 80 °C / Inert atmosphere

2: palladium on activated carbon; hydrogen / ethanol; ethyl acetate / 16 h / 20 °C

3: sodium methylate / methanol / 20 h / Reflux

With copper(l) iodide; palladium on activated carbon; hydrogen; sodium methylate; potassium carbonate; L-proline; In methanol; ethanol; dimethyl sulfoxide; ethyl acetate;