1-(2-chlorophenyl)-5-(3-methanesulfonylphenylethynyl)-3-trifluoromethyl-1H-pyrazole

Base Information

Chemical Name:1-(2-chlorophenyl)-5-(3-methanesulfonylphenylethynyl)-3-trifluoromethyl-1H-pyrazole
CAS No.:1033575-73-3
Molecular Formula:C₁₉H₁₂ClF₃N₂O₂S
Molecular Weight:424.831
Hs Code.:

Synonyms:1-(2-chlorophenyl)-5-(3-methanesulfonylphenylethynyl)-3-trifluoromethyl-1H-pyrazole

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Chemical Property of 1-(2-chlorophenyl)-5-(3-methanesulfonylphenylethynyl)-3-trifluoromethyl-1H-pyrazole

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Technology Process of 1-(2-chlorophenyl)-5-(3-methanesulfonylphenylethynyl)-3-trifluoromethyl-1H-pyrazole

There total 4 articles about 1-(2-chlorophenyl)-5-(3-methanesulfonylphenylethynyl)-3-trifluoromethyl-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 573982-84-0
1-ethynyl-3-(methylsulfonyl)benzene

: 918327-95-4
trifluoromethanesulfonic acid 2-(2-chlorophenyl)-5-trifluoromethyl-2H-pyrazol-3-yl ester

: 1033575-73-3
1-(2-chlorophenyl)-5-(3-methanesulfonylphenylethynyl)-3-trifluoromethyl-1H-pyrazole

Guidance literature:: With triethylamine; palladium diacetate; copper(l) iodide; triphenylphosphine; In tetrahydrofuran; at 90 ℃; for 1h;

Reference yield:

: 910122-89-3
(3-methanesulfonylphenylethynyl)trimethylsilane

: 1033575-73-3
1-(2-chlorophenyl)-5-(3-methanesulfonylphenylethynyl)-3-trifluoromethyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: methanol; potassium carbonate / 3 h / 20 °C

2: triethylamine / palladium diacetate; copper(l) iodide; triphenylphosphine / tetrahydrofuran / 1 h / 90 °C

With methanol; potassium carbonate; triethylamine; palladium diacetate; copper(l) iodide; triphenylphosphine; In tetrahydrofuran;

Reference yield:

: 918328-47-9
1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-ol

: 1033575-73-3
1-(2-chlorophenyl)-5-(3-methanesulfonylphenylethynyl)-3-trifluoromethyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: 2,6-di-tert-butyl-4-methylpyridine / dichloromethane / 3 h / 0 - 20 °C

2: triethylamine / palladium diacetate; copper(l) iodide; triphenylphosphine / tetrahydrofuran / 1 h / 90 °C

With 2,6-di-tert-butyl-4-methylpyridine; triethylamine; palladium diacetate; copper(l) iodide; triphenylphosphine; In tetrahydrofuran; dichloromethane;