(E)-methyl 3-(2-(2-(4-methylphenylsulfonamido)ethyl)phenyl)acrylate

Base Information

• Chemical Name: (E)-methyl 3-(2-(2-(4-methylphenylsulfonamido)ethyl)phenyl)acrylate
• CAS No.: 1311201-40-7
• Molecular Formula: C₁₉H₂₁NO₄S
• Molecular Weight: 359.446
• Mol file: 1311201-40-7.mol

Synonyms:(E)-methyl 3-(2-(2-(4-methylphenylsulfonamido)ethyl)phenyl)acrylate

Chemical Property of (E)-methyl 3-(2-(2-(4-methylphenylsulfonamido)ethyl)phenyl)acrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-methyl 3-(2-(2-(4-methylphenylsulfonamido)ethyl)phenyl)acrylate

There total 1 articles about (E)-methyl 3-(2-(2-(4-methylphenylsulfonamido)ethyl)phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) + N-[(4-methylphenyl)sulfonyl]-2-(2-bromophenyl)ethylamine (543745-58-0) → (E)-methyl 3-(2-(2-(4-methylphenylsulfonamido)ethyl)phenyl)acrylate (1311201-40-7)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; triethylamine; In N,N-dimethyl-formamide; at 90 ℃; for 62h; Inert atmosphere;

DOI:10.1002/anie.201100772

Reference yield: 84.0%

(E)-methyl 3-(2-(2-(4-methylphenylsulfonamido)ethyl)phenyl)acrylate (1311201-40-7) → (E)-N-(2-(3-hydroxyprop-1-enyl)phenethyl)-4-methylbenzenesulfonamide (1311201-41-8)

Guidance literature:

(E)-methyl 3-(2-(2-(4-methylphenylsulfonamido)ethyl)phenyl)acrylate; With diisobutylaluminium hydride; In diethyl ether; hexane; at -78 ℃; for 2h; Inert atmosphere;

With water; potassium carbonate; In diethyl ether; hexane; at 25 - 28 ℃; for 0.5h; Inert atmosphere; Saturated solution;

DOI:10.1002/anie.201100772

Reference yield:

(E)-methyl 3-(2-(2-(4-methylphenylsulfonamido)ethyl)phenyl)acrylate (1311201-40-7) → (-)-2-tosyl-1-vinyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:

Multi-step reaction with 2 steps

1.1: diisobutylaluminium hydride / diethyl ether; hexane / 2 h / -78 °C / Inert atmosphere

1.2: 0.5 h / 25 - 28 °C / Inert atmosphere; Saturated solution

2.1: cyclopentadienylruthenium(II) trisacetonitrile hexafluorophosphate; (3aR,11aR,14aS,16bS)-2,2,13,13-tetra-isopropyl-3a,11a,14a,16b-tetrahydro-bis(1,3-dioxolano[4',5':3,4]pyrrolo)[1,2-a:1',2'-a]naphtho[1,2-d:8,7-d']diimidazole; toluene-4-sulfonic acid / dichloromethane / 1 h / 60 °C / Inert atmosphere

With cyclopentadienylruthenium(II) trisacetonitrile hexafluorophosphate; (3aR,11aR,14aS,16bS)-2,2,13,13-tetra-isopropyl-3a,11a,14a,16b-tetrahydro-bis(1,3-dioxolano[4',5':3,4]pyrrolo)[1,2-a:1',2'-a]naphtho[1,2-d:8,7-d']diimidazole; diisobutylaluminium hydride; toluene-4-sulfonic acid; In diethyl ether; hexane; dichloromethane;

DOI:10.1002/anie.201100772

upstream raw materials:

acrylic acid methyl ester

N-[(4-methylphenyl)sulfonyl]-2-(2-bromophenyl)ethylamine

Downstream raw materials:

(E)-N-(2-(3-hydroxyprop-1-enyl)phenethyl)-4-methylbenzenesulfonamide