Technology Process of (E)-N-(2-(3-hydroxyprop-1-enyl)phenethyl)-4-methylbenzenesulfonamide
There total 2 articles about (E)-N-(2-(3-hydroxyprop-1-enyl)phenethyl)-4-methylbenzenesulfonamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(E)-methyl 3-(2-(2-(4-methylphenylsulfonamido)ethyl)phenyl)acrylate;
With
diisobutylaluminium hydride;
In
diethyl ether; hexane;
at -78 ℃;
for 2h;
Inert atmosphere;
With
water; potassium carbonate;
In
diethyl ether; hexane;
at 25 - 28 ℃;
for 0.5h;
Inert atmosphere;
Saturated solution;
DOI:10.1002/anie.201100772
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 62 h / 90 °C / Inert atmosphere
2.1: diisobutylaluminium hydride / diethyl ether; hexane / 2 h / -78 °C / Inert atmosphere
2.2: 0.5 h / 25 - 28 °C / Inert atmosphere; Saturated solution
With
bis-triphenylphosphine-palladium(II) chloride; diisobutylaluminium hydride; triethylamine;
In
diethyl ether; hexane; N,N-dimethyl-formamide;
DOI:10.1002/anie.201100772
- Guidance literature:
-
With
cyclopentadienylruthenium(II) trisacetonitrile hexafluorophosphate; (3aR,11aR,14aS,16bS)-2,2,13,13-tetra-isopropyl-3a,11a,14a,16b-tetrahydro-bis(1,3-dioxolano[4',5':3,4]pyrrolo)[1,2-a:1',2'-a]naphtho[1,2-d:8,7-d']diimidazole; toluene-4-sulfonic acid;
In
dichloromethane;
at 60 ℃;
for 1h;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
DOI:10.1002/anie.201100772
