N-(3-(2-methoxyphenyl)prop-2-yn-1-yl)-4-methyl-N-(phenylethynyl)benzenesulfonamide

Base Information

Chemical Name:N-(3-(2-methoxyphenyl)prop-2-yn-1-yl)-4-methyl-N-(phenylethynyl)benzenesulfonamide
CAS No.:1437787-93-3
Molecular Formula:C₂₅H₂₁NO₃S
Molecular Weight:415.513
Hs Code.:

Synonyms:N-(3-(2-methoxyphenyl)prop-2-yn-1-yl)-4-methyl-N-(phenylethynyl)benzenesulfonamide

Suppliers and Price of N-(3-(2-methoxyphenyl)prop-2-yn-1-yl)-4-methyl-N-(phenylethynyl)benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3-(2-methoxyphenyl)prop-2-yn-1-yl)-4-methyl-N-(phenylethynyl)benzenesulfonamide

Chemical Property:

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Technology Process of N-(3-(2-methoxyphenyl)prop-2-yn-1-yl)-4-methyl-N-(phenylethynyl)benzenesulfonamide

There total 4 articles about N-(3-(2-methoxyphenyl)prop-2-yn-1-yl)-4-methyl-N-(phenylethynyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1437788-80-1
C₁₇H₁₇NO₃S

: 932-87-6
1-Bromo-2-phenylacetylene

: 1437787-93-3
N-(3-(2-methoxyphenyl)prop-2-yn-1-yl)-4-methyl-N-(phenylethynyl)benzenesulfonamide

Guidance literature:: With 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; potassium carbonate; In toluene; at 65 - 75 ℃; for 32h; Inert atmosphere;
DOI:10.1021/ja4047069

Reference yield:

: 529-28-2
4-iodoanisol

: 1437787-93-3
N-(3-(2-methoxyphenyl)prop-2-yn-1-yl)-4-methyl-N-(phenylethynyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 19 h / 50 °C / Inert atmosphere

2: potassium carbonate; copper(ll) sulfate pentahydrate; 1,10-Phenanthroline / toluene / 32 h / 65 - 75 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; potassium carbonate; triethylamine; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja4047069

Reference yield:

: 18303-04-3
N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide

: 1437787-93-3
N-(3-(2-methoxyphenyl)prop-2-yn-1-yl)-4-methyl-N-(phenylethynyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / Inert atmosphere

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

3: copper(ll) sulfate pentahydrate; 1,10-Phenanthroline; potassium phosphate / toluene / 70 °C / Inert atmosphere; Schlenk technique

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; copper(l) iodide; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; 1: |Mitsunobu Displacement / 2: |Sonogashira Cross-Coupling;
DOI:10.1002/chem.201301599