N-(3-(2-methoxyphenyl)prop-2-yn-1-yl)-4-methyl-N-(phenylethynyl)benzenesulfonamide

Base Information

• Chemical Name: N-(3-(2-methoxyphenyl)prop-2-yn-1-yl)-4-methyl-N-(phenylethynyl)benzenesulfonamide
• CAS No.: 1437787-93-3
• Molecular Formula: C₂₅H₂₁NO₃S
• Molecular Weight: 415.513
• Mol file: 1437787-93-3.mol

Synonyms:N-(3-(2-methoxyphenyl)prop-2-yn-1-yl)-4-methyl-N-(phenylethynyl)benzenesulfonamide

Chemical Property of N-(3-(2-methoxyphenyl)prop-2-yn-1-yl)-4-methyl-N-(phenylethynyl)benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-(2-methoxyphenyl)prop-2-yn-1-yl)-4-methyl-N-(phenylethynyl)benzenesulfonamide

There total 4 articles about N-(3-(2-methoxyphenyl)prop-2-yn-1-yl)-4-methyl-N-(phenylethynyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C17H17NO3S (1437788-80-1) + 1-Bromo-2-phenylacetylene (932-87-6) → N-(3-(2-methoxyphenyl)prop-2-yn-1-yl)-4-methyl-N-(phenylethynyl)benzenesulfonamide (1437787-93-3)

Guidance literature:

With 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; potassium carbonate; In toluene; at 65 - 75 ℃; for 32h; Inert atmosphere;

DOI:10.1021/ja4047069

Reference yield:

4-iodoanisol (529-28-2) → N-(3-(2-methoxyphenyl)prop-2-yn-1-yl)-4-methyl-N-(phenylethynyl)benzenesulfonamide (1437787-93-3)

Guidance literature:

Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 19 h / 50 °C / Inert atmosphere

2: potassium carbonate; copper(ll) sulfate pentahydrate; 1,10-Phenanthroline / toluene / 32 h / 65 - 75 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; potassium carbonate; triethylamine; In N,N-dimethyl-formamide; toluene;

DOI:10.1021/ja4047069

Reference yield:

N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide (18303-04-3) → N-(3-(2-methoxyphenyl)prop-2-yn-1-yl)-4-methyl-N-(phenylethynyl)benzenesulfonamide (1437787-93-3)

Guidance literature:

Multi-step reaction with 3 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / Inert atmosphere

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

3: copper(ll) sulfate pentahydrate; 1,10-Phenanthroline; potassium phosphate / toluene / 70 °C / Inert atmosphere; Schlenk technique

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; copper(l) iodide; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; 1: |Mitsunobu Displacement / 2: |Sonogashira Cross-Coupling;

DOI:10.1002/chem.201301599

upstream raw materials:

4-iodoanisol

C₁₇H₁₇NO₃S

1-Bromo-2-phenylacetylene

N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide

Downstream raw materials:

C₂₅H₂₁NO₅S