(1S,2R,10bS)-1,2-dihydroxy-1,2,3,5,6,10bβ-hexahydropyrrolo<2,1-a>isoquinolin-3(2H)-one

Base Information

• Chemical Name: (1S,2R,10bS)-1,2-dihydroxy-1,2,3,5,6,10bβ-hexahydropyrrolo<2,1-a>isoquinolin-3(2H)-one
• CAS No.: 164736-96-3
• Molecular Formula: C₁₂H₁₃NO₃
• Molecular Weight: 219.24
• Mol file: 164736-96-3.mol

Synonyms:(1S,2R,10bS)-1,2-dihydroxy-1,2,3,5,6,10bβ-hexahydropyrrolo<2,1-a>isoquinolin-3(2H)-one

Chemical Property of (1S,2R,10bS)-1,2-dihydroxy-1,2,3,5,6,10bβ-hexahydropyrrolo<2,1-a>isoquinolin-3(2H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2R,10bS)-1,2-dihydroxy-1,2,3,5,6,10bβ-hexahydropyrrolo<2,1-a>isoquinolin-3(2H)-one

There total 6 articles about (1S,2R,10bS)-1,2-dihydroxy-1,2,3,5,6,10bβ-hexahydropyrrolo<2,1-a>isoquinolin-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(1S,2R,10bS)-1,2-diacetoxy-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinolin-3-one → (1S,2R,10bS)-1,2-dihydroxy-1,2,3,5,6,10bβ-hexahydropyrrolo<2,1-a>isoquinolin-3(2H)-one (164736-96-3,524950-94-5)

Guidance literature:

With methanol; acetyl chloride; at 0 - 20 ℃; for 3h;

DOI:10.1016/S0957-4166(02)00785-1

Reference yield: 55.0%

(3R,4R)-5-ethoxy-3,4-dihydroxy-1-(2-phenylethyl)-2-pyrrolidinone → (1S,2R,10bS)-1,2-dihydroxy-1,2,3,5,6,10bβ-hexahydropyrrolo<2,1-a>isoquinolin-3(2H)-one (164736-96-3,524950-94-5)

Guidance literature:

With formaldehyd; for 17h; Heating;

DOI:10.1080/00397919508015871

Reference yield: 36.0%

(3R,4R)-3,4,5-trihydroxy-1-(2-phenylethyl)-2-pyrrolidinone → (1S,2R,10bS)-1,2-dihydroxy-1,2,3,5,6,10bβ-hexahydropyrrolo<2,1-a>isoquinolin-3(2H)-one (164736-96-3,524950-94-5)

Guidance literature:

With boron trifluoride diethyl etherate; for 14h; Ambient temperature;

DOI:10.1080/00397919508015871

upstream raw materials:

phenethylamine

(3R,4R)-3,4-dihydroxy-1-(2-phenylethyl)-2,5-pyrrolidinedione

Downstream raw materials:

(1S,2R,10bS)-2-benzoyloxy-1-hydroxy-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinolin-3-one

(1S,2S,10bS)-1,2-dihydroxy-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinolin-3-one

(1R,2R,10bS)-1,2-dihydroxy-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinolin-3-one

(1S,2S,10bS)-1-benzoyloxy-2-hydroxy-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinolin-3-one