(R)-2-tert-Butoxycarbonylamino-6-(N',N''-dicyclohexyl-guanidino)-hexanoic acid; compound with toluene-4-sulfonic acid

Base Information

Chemical Name:(R)-2-tert-Butoxycarbonylamino-6-(N',N''-dicyclohexyl-guanidino)-hexanoic acid; compound with toluene-4-sulfonic acid
CAS No.:110798-12-4
Molecular Formula:C₇H₈O₃S*C₂₄H₄₄N₄O₄
Molecular Weight:624.842
Hs Code.:

Synonyms:(R)-2-tert-Butoxycarbonylamino-6-(N',N''-dicyclohexyl-guanidino)-hexanoic acid; compound with toluene-4-sulfonic acid

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Chemical Property of (R)-2-tert-Butoxycarbonylamino-6-(N',N''-dicyclohexyl-guanidino)-hexanoic acid; compound with toluene-4-sulfonic acid

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Technology Process of (R)-2-tert-Butoxycarbonylamino-6-(N',N''-dicyclohexyl-guanidino)-hexanoic acid; compound with toluene-4-sulfonic acid

There total 4 articles about (R)-2-tert-Butoxycarbonylamino-6-(N',N''-dicyclohexyl-guanidino)-hexanoic acid; compound with toluene-4-sulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 110798-06-6
(R)-2-Amino-6-(N',N''-dicyclohexyl-guanidino)-hexanoic acid; compound with toluene-4-sulfonic acid

: 110798-12-4
(R)-2-tert-Butoxycarbonylamino-6-(N',N''-dicyclohexyl-guanidino)-hexanoic acid; compound with toluene-4-sulfonic acid

Guidance literature:: With sodium hydroxide; magnesium oxide; In 1,4-dioxane; water; 1.) 0 deg C, 1 h, 2.) room temperature, 1 h;
DOI:10.1021/jm00396a011

Reference yield:

: 89662-37-3
benzyl N^α-(benzyloxycarbonyl)-D-lysine toluenesulfonate

: 110798-12-4
(R)-2-tert-Butoxycarbonylamino-6-(N',N''-dicyclohexyl-guanidino)-hexanoic acid; compound with toluene-4-sulfonic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / tri(cyclohexyl)amine / 2-methyl-propan-2-ol / 18 h / 100 °C

2: 100 percent / H₂ / Pd/C / ethanol / 4 h

3: 94 percent / NaOH, MgO / H₂O; dioxane / 1.) 0 deg C, 1 h, 2.) room temperature, 1 h

With sodium hydroxide; tri(cyclohexyl)amine; hydrogen; magnesium oxide; palladium on activated charcoal; In 1,4-dioxane; ethanol; water; tert-butyl alcohol;
DOI:10.1021/jm00396a011

Reference yield:

: 538-75-0
dicyclohexyl-carbodiimide

: 110798-12-4
(R)-2-tert-Butoxycarbonylamino-6-(N',N''-dicyclohexyl-guanidino)-hexanoic acid; compound with toluene-4-sulfonic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / tri(cyclohexyl)amine / 2-methyl-propan-2-ol / 18 h / 100 °C

2: 100 percent / H₂ / Pd/C / ethanol / 4 h

3: 94 percent / NaOH, MgO / H₂O; dioxane / 1.) 0 deg C, 1 h, 2.) room temperature, 1 h

With sodium hydroxide; tri(cyclohexyl)amine; hydrogen; magnesium oxide; palladium on activated charcoal; In 1,4-dioxane; ethanol; water; tert-butyl alcohol;
DOI:10.1021/jm00396a011