5-{5-[3-(1-methanesulfonyl-piperidin-4-yl)-3-phenyl-propyl]-hexahydro-pyrrolo[3,4-c]pyrrole-2-carbonyl}-4,6-dimethyl-pyridine-2-carbonitrile

Base Information

Chemical Name:5-{5-[3-(1-methanesulfonyl-piperidin-4-yl)-3-phenyl-propyl]-hexahydro-pyrrolo[3,4-c]pyrrole-2-carbonyl}-4,6-dimethyl-pyridine-2-carbonitrile
CAS No.:1014702-02-3
Molecular Formula:C₃₀H₃₉N₅O₃S
Molecular Weight:549.737
Hs Code.:

Synonyms:5-{5-[3-(1-methanesulfonyl-piperidin-4-yl)-3-phenyl-propyl]-hexahydro-pyrrolo[3,4-c]pyrrole-2-carbonyl}-4,6-dimethyl-pyridine-2-carbonitrile

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Chemical Property of 5-{5-[3-(1-methanesulfonyl-piperidin-4-yl)-3-phenyl-propyl]-hexahydro-pyrrolo[3,4-c]pyrrole-2-carbonyl}-4,6-dimethyl-pyridine-2-carbonitrile

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Technology Process of 5-{5-[3-(1-methanesulfonyl-piperidin-4-yl)-3-phenyl-propyl]-hexahydro-pyrrolo[3,4-c]pyrrole-2-carbonyl}-4,6-dimethyl-pyridine-2-carbonitrile

There total 4 articles about 5-{5-[3-(1-methanesulfonyl-piperidin-4-yl)-3-phenyl-propyl]-hexahydro-pyrrolo[3,4-c]pyrrole-2-carbonyl}-4,6-dimethyl-pyridine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: C₂₉H₃₇N₅O

: 124-63-0
methanesulfonyl chloride

: 1014702-02-3
5-{5-[3-(1-methanesulfonyl-piperidin-4-yl)-3-phenyl-propyl]-hexahydro-pyrrolo[3,4-c]pyrrole-2-carbonyl}-4,6-dimethyl-pyridine-2-carbonitrile

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: 527693-93-2
3-phenyl-3-(1-tert-butyloxycarbonylpiperidin-4-yl)propionaldehyde

: 1014702-02-3
5-{5-[3-(1-methanesulfonyl-piperidin-4-yl)-3-phenyl-propyl]-hexahydro-pyrrolo[3,4-c]pyrrole-2-carbonyl}-4,6-dimethyl-pyridine-2-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 0 - 20 °C

2: hydrogen / palladium(II) hydroxide/carbon / ethanol / 24 h

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 36 h / 0 - 20 °C

4: trifluoroacetic acid / 1 h / 20 °C

5: triethylamine / tetrahydrofuran / 0 - 20 °C

With hydrogen; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; palladium(II) hydroxide/carbon; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 1014702-97-6
C₃₂H₄₅N₃O₂

: 1014702-02-3
5-{5-[3-(1-methanesulfonyl-piperidin-4-yl)-3-phenyl-propyl]-hexahydro-pyrrolo[3,4-c]pyrrole-2-carbonyl}-4,6-dimethyl-pyridine-2-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium(II) hydroxide/carbon / ethanol / 24 h

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 36 h / 0 - 20 °C

3: trifluoroacetic acid / 1 h / 20 °C

4: triethylamine / tetrahydrofuran / 0 - 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; palladium(II) hydroxide/carbon; In tetrahydrofuran; ethanol; dichloromethane;