1-methylethyl {(2S,4R)-1-acetyl-2-methyl-6-[4-(1-piperidinyl methyl)phenyl]-1,2,3,4-tetrahydro-4-quinolinyl}carbamate

Base Information

Chemical Name:1-methylethyl {(2S,4R)-1-acetyl-2-methyl-6-[4-(1-piperidinyl methyl)phenyl]-1,2,3,4-tetrahydro-4-quinolinyl}carbamate
CAS No.:1300695-75-3
Molecular Formula:C₂₈H₃₇N₃O₃
Molecular Weight:463.62
Hs Code.:

Synonyms:1-methylethyl {(2S,4R)-1-acetyl-2-methyl-6-[4-(1-piperidinyl methyl)phenyl]-1,2,3,4-tetrahydro-4-quinolinyl}carbamate

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Chemical Property of 1-methylethyl {(2S,4R)-1-acetyl-2-methyl-6-[4-(1-piperidinyl methyl)phenyl]-1,2,3,4-tetrahydro-4-quinolinyl}carbamate

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Technology Process of 1-methylethyl {(2S,4R)-1-acetyl-2-methyl-6-[4-(1-piperidinyl methyl)phenyl]-1,2,3,4-tetrahydro-4-quinolinyl}carbamate

There total 11 articles about 1-methylethyl {(2S,4R)-1-acetyl-2-methyl-6-[4-(1-piperidinyl methyl)phenyl]-1,2,3,4-tetrahydro-4-quinolinyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.9%

: 110-89-4
piperidine

: 1300031-96-2
1-methylethyl [(2S,4R)-1-acetyl-6-(4-formylphenyl)-2-methyl-1,2,3,4-tetrahydro-4-quinolinyl]carbamate

: 1300695-75-3
1-methylethyl {(2S,4R)-1-acetyl-2-methyl-6-[4-(1-piperidinyl methyl)phenyl]-1,2,3,4-tetrahydro-4-quinolinyl}carbamate

Guidance literature:: piperidine; 1-methylethyl [(2S,4R)-1-acetyl-6-(4-formylphenyl)-2-methyl-1,2,3,4-tetrahydro-4-quinolinyl]carbamate; With acetic acid; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 60h;

Reference yield:

: 1300031-98-4
1-methylethyl [(2S,4R)-1-acetyl-6-bromo-2-methyl-1,2,3,4-tetrahydro-4-quinolinyl]carbamate

: 1301198-10-6
[4-(1-piperidinylmethyl)phenyl]boronic acid hydrochloride

: 1300695-75-3
1-methylethyl {(2S,4R)-1-acetyl-2-methyl-6-[4-(1-piperidinyl methyl)phenyl]-1,2,3,4-tetrahydro-4-quinolinyl}carbamate

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; toluene; at 90 - 100 ℃; for 26h; Microwave irradiation;

Reference yield:

: 106-40-1
4-bromo-aniline

: 1300695-75-3
1-methylethyl {(2S,4R)-1-acetyl-2-methyl-6-[4-(1-piperidinyl methyl)phenyl]-1,2,3,4-tetrahydro-4-quinolinyl}carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: ((R)-BINAP)ditriflatebis(acetonitrile)palladium(II) / toluene

2: sodium tetrahydroborate; magnesium(II) chloride hexahydrate / ethanol; water / 2 h / -10 - 20 °C

3: pyridine / dichloromethane / Inert atmosphere

4: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol / 3 h / 100 °C / Microwave irradiation

With pyridine; sodium tetrahydroborate; magnesium(II) chloride hexahydrate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ((R)-BINAP)ditriflatebis(acetonitrile)palladium(II); In ethanol; dichloromethane; water; toluene;