4-((2-isopropyl-5-methylphenoxy)methyl)-1-phenyl-1H-1,2,3-triazole

Base Information

• Chemical Name: 4-((2-isopropyl-5-methylphenoxy)methyl)-1-phenyl-1H-1,2,3-triazole
• CAS No.: 1442115-80-1
• Molecular Formula: C₁₉H₂₁N₃O
• Molecular Weight: 307.395
• Mol file: 1442115-80-1.mol

Synonyms:4-((2-isopropyl-5-methylphenoxy)methyl)-1-phenyl-1H-1,2,3-triazole

Chemical Property of 4-((2-isopropyl-5-methylphenoxy)methyl)-1-phenyl-1H-1,2,3-triazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-((2-isopropyl-5-methylphenoxy)methyl)-1-phenyl-1H-1,2,3-triazole

There total 3 articles about 4-((2-isopropyl-5-methylphenoxy)methyl)-1-phenyl-1H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-isopropyl-4-methyl-2-(prop-2-ynyloxy)benzene (17727-38-7) + Phenyl azide (622-37-7) → 4-((2-isopropyl-5-methylphenoxy)methyl)-1-phenyl-1H-1,2,3-triazole (1442115-80-1)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; at 90 - 110 ℃; Microwave irradiation;

DOI:10.1080/00304948.2013.786575

Reference yield:

thymol (89-83-8) → 4-((2-isopropyl-5-methylphenoxy)methyl)-1-phenyl-1H-1,2,3-triazole (1442115-80-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / acetone / 1 h / Reflux

1.2: 5 h / 50 - 60 °C

2.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 20 - 30 °C

2.2: 20 - 30 °C

With copper(ll) sulfate pentahydrate; potassium carbonate; sodium L-ascorbate; In water; acetone; tert-butyl alcohol;

DOI:10.1016/j.bmc.2021.116136

Reference yield:

aniline (62-53-3) → 4-((2-isopropyl-5-methylphenoxy)methyl)-1-phenyl-1H-1,2,3-triazole (1442115-80-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium nitrite; hydrogenchloride / water

1.2: 0 - 5 °C

2.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 20 - 30 °C

2.2: 20 - 30 °C

With hydrogenchloride; copper(ll) sulfate pentahydrate; sodium L-ascorbate; sodium nitrite; In water; tert-butyl alcohol;

DOI:10.1016/j.bmc.2021.116136

upstream raw materials:

1-isopropyl-4-methyl-2-(prop-2-ynyloxy)benzene

Phenyl azide

thymol

aniline