(2R,4R,5R)-methyl 2-(4-chlorophenyl)-1-(4-methoxyphenyl)-5-(perfluoroethyl)-imidazolidine-4-carboxylate

Base Information

Chemical Name:(2R,4R,5R)-methyl 2-(4-chlorophenyl)-1-(4-methoxyphenyl)-5-(perfluoroethyl)-imidazolidine-4-carboxylate
CAS No.:1428259-75-9
Molecular Formula:C₂₀H₁₈ClF₅N₂O₃
Molecular Weight:464.82
Hs Code.:

Synonyms:(2R,4R,5R)-methyl 2-(4-chlorophenyl)-1-(4-methoxyphenyl)-5-(perfluoroethyl)-imidazolidine-4-carboxylate

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Chemical Property of (2R,4R,5R)-methyl 2-(4-chlorophenyl)-1-(4-methoxyphenyl)-5-(perfluoroethyl)-imidazolidine-4-carboxylate

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Technology Process of (2R,4R,5R)-methyl 2-(4-chlorophenyl)-1-(4-methoxyphenyl)-5-(perfluoroethyl)-imidazolidine-4-carboxylate

There total 2 articles about (2R,4R,5R)-methyl 2-(4-chlorophenyl)-1-(4-methoxyphenyl)-5-(perfluoroethyl)-imidazolidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 189396-84-7
C₁₀H₈F₅NO

: 76862-09-4
methyl N-(4-chlorobenzylidene)glycinate

: 1428259-75-9
(2R,4R,5R)-methyl 2-(4-chlorophenyl)-1-(4-methoxyphenyl)-5-(perfluoroethyl)-imidazolidine-4-carboxylate

Guidance literature:: With tetrakis(acetonitrile)copper(I)tetrafluoroborate; C₂₅H₂₅FeOP; triethylamine; In diethyl ether; at -20 ℃; enantioselective reaction; Inert atmosphere;
DOI:10.1039/c3cc43025a DOI:10.1039/c3cc43025a

Reference yield:

: 104-94-9
4-methoxy-aniline

: 1428259-75-9
(2R,4R,5R)-methyl 2-(4-chlorophenyl)-1-(4-methoxyphenyl)-5-(perfluoroethyl)-imidazolidine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / toluene / 1.5 h / Reflux; Inert atmosphere; Dean-Stark

2: tetrakis(acetonitrile)copper(I)tetrafluoroborate; triethylamine; C₂₅H₂₅FeOP / diethyl ether / -20 - 20 °C / Inert atmosphere

With tetrakis(acetonitrile)copper(I)tetrafluoroborate; C₂₅H₂₅FeOP; toluene-4-sulfonic acid; triethylamine; In diethyl ether; toluene;
DOI:10.1021/acs.joc.8b01743