Acetylderivat des 4-Desmethyl-7'-dehydroxy-podophyllotoxins

Base Information

• Chemical Name: Acetylderivat des 4-Desmethyl-7'-dehydroxy-podophyllotoxins
• CAS No.: 111142-77-9
• Molecular Formula: C₂₃H₂₂O₈
• Molecular Weight: 426.423
• Mol file: 111142-77-9.mol

Synonyms:Acetylderivat des 4-Desmethyl-7'-dehydroxy-podophyllotoxins

Chemical Property of Acetylderivat des 4-Desmethyl-7'-dehydroxy-podophyllotoxins

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetylderivat des 4-Desmethyl-7'-dehydroxy-podophyllotoxins

There total 4 articles about Acetylderivat des 4-Desmethyl-7'-dehydroxy-podophyllotoxins which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4'-demethyl-4-deoxypodophyllotoxin (3590-93-0,85440-15-9,123287-54-7,123287-57-0) + acetic acid (64-19-7,77671-22-8) → Acetylderivat des 4-Desmethyl-7'-dehydroxy-podophyllotoxins (111142-77-9)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1016/j.ejmech.2003.10.002

Reference yield:

deoxypodophyllotoxin (477-51-0,6258-33-9,17187-81-4,17301-90-5,19186-35-7,24150-39-8,31892-96-3,55568-81-5,64550-41-0,69222-20-4,75171-57-2,83023-41-0,100348-38-7) → Acetylderivat des 4-Desmethyl-7'-dehydroxy-podophyllotoxins (111142-77-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trimethylsilyl iodide / CH₂Cl₂ / 5 h / 0 °C

1.2: 72 percent / BaCO₃ / 0.5 h

2.1: 85 percent / dicyclohexylcarbodiimide; 4-dimethylaminopyridine / CH₂Cl₂ / 2 h / 0 °C

With dmap; trimethylsilyl iodide; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1016/j.ejmech.2003.10.002

Reference yield:

4'-demethyl-4-deoxypodophyllotoxin (3590-93-0,85440-15-9,123287-54-7,123287-57-0) + acetic anhydride (108-24-7) → Acetylderivat des 4-Desmethyl-7'-dehydroxy-podophyllotoxins (111142-77-9)

Guidance literature:

With pyridine;

DOI:10.1021/jm960023h

upstream raw materials:

4'-demethyl-4-deoxypodophyllotoxin

acetic anhydride

acetic acid

deoxypodophyllotoxin