2-bromo-6-nitrophenylacetylene dicyclohexylphosphine oxide

Base Information

Chemical Name:2-bromo-6-nitrophenylacetylene dicyclohexylphosphine oxide
CAS No.:916978-60-4
Molecular Formula:C₂₀H₂₅BrNO₃P
Molecular Weight:438.301
Hs Code.:

Synonyms:2-bromo-6-nitrophenylacetylene dicyclohexylphosphine oxide

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Chemical Property of 2-bromo-6-nitrophenylacetylene dicyclohexylphosphine oxide

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Technology Process of 2-bromo-6-nitrophenylacetylene dicyclohexylphosphine oxide

There total 4 articles about 2-bromo-6-nitrophenylacetylene dicyclohexylphosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 916978-57-9
6-bromo-2-nitrophenylacetylene

: 15873-72-0
dicyclohexylphosphinoyl chloride

: 916978-60-4
2-bromo-6-nitrophenylacetylene dicyclohexylphosphine oxide

Guidance literature:: 6-bromo-2-nitrophenylacetylene; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h;

dicyclohexylphosphinoyl chloride; In tetrahydrofuran; hexane; at -78 - 20 ℃;
DOI:10.1002/anie.200602683

Reference yield:

: 20357-21-5
2-bromo-6-nitrobenzaldehyde

: 916978-60-4
2-bromo-6-nitrophenylacetylene dicyclohexylphosphine oxide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 85 percent / K₂CO₃; methanol / 2 h / 20 °C

2.1: LDA / tetrahydrofuran; hexane / 0.17 h / -78 °C

2.2: 90 percent / tetrahydrofuran; hexane / -78 - 20 °C

With methanol; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; hexane;
DOI:10.1021/ja071163r

Reference yield:

2-bromo-6-nitrotoluene: 55289-35-5
2-bromo-6-nitrotoluene

: 916978-60-4
2-bromo-6-nitrophenylacetylene dicyclohexylphosphine oxide

Guidance literature:: Multi-step reaction with 4 steps

1.1: dimethylformamide / 16 h / 135 °C

2.1: 3.44 g / NaIO₄ / dimethylformamide; H₂O / 22 h / 0 - 20 °C

3.1: 85 percent / K₂CO₃; methanol / 2 h / 20 °C

4.1: LDA / tetrahydrofuran; hexane / 0.17 h / -78 °C

4.2: 90 percent / tetrahydrofuran; hexane / -78 - 20 °C

With methanol; sodium periodate; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide;
DOI:10.1021/ja071163r