methyl 2-((2-(3,4-difluorophenyl)-5-hydroxy-4-oxo-4H-chromen-7-yl)oxy)acetate

Base Information

Chemical Name:methyl 2-((2-(3,4-difluorophenyl)-5-hydroxy-4-oxo-4H-chromen-7-yl)oxy)acetate
CAS No.:1447463-66-2
Molecular Formula:C₁₈H₁₂F₂O₆
Molecular Weight:362.286
Hs Code.:

Synonyms:methyl 2-((2-(3,4-difluorophenyl)-5-hydroxy-4-oxo-4H-chromen-7-yl)oxy)acetate

Suppliers and Price of methyl 2-((2-(3,4-difluorophenyl)-5-hydroxy-4-oxo-4H-chromen-7-yl)oxy)acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 2-((2-(3,4-difluorophenyl)-5-hydroxy-4-oxo-4H-chromen-7-yl)oxy)acetate

Chemical Property:

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Technology Process of methyl 2-((2-(3,4-difluorophenyl)-5-hydroxy-4-oxo-4H-chromen-7-yl)oxy)acetate

There total 2 articles about methyl 2-((2-(3,4-difluorophenyl)-5-hydroxy-4-oxo-4H-chromen-7-yl)oxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 367-11-3
ortho-difluorobenzene

: C₁₂H₁₀O₆

: 1447463-66-2
methyl 2-((2-(3,4-difluorophenyl)-5-hydroxy-4-oxo-4H-chromen-7-yl)oxy)acetate

Guidance literature:: With palladium(II) trifluoroacetate; silver(I) acetate; cesium pivalate; Trimethylacetic acid; at 100 ℃; regioselective reaction; Inert atmosphere;
DOI:10.1016/j.bmcl.2013.05.095

Reference yield:

: 31721-94-5
5,7-dihydroxy-chromen-4-one

: 1447463-66-2
methyl 2-((2-(3,4-difluorophenyl)-5-hydroxy-4-oxo-4H-chromen-7-yl)oxy)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

2: palladium(II) trifluoroacetate; silver(I) acetate; cesium pivalate; Trimethylacetic acid / 100 °C / Inert atmosphere

With palladium(II) trifluoroacetate; silver(I) acetate; potassium carbonate; cesium pivalate; Trimethylacetic acid; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.05.095

Reference yield: 99.0%

: 1447463-66-2
methyl 2-((2-(3,4-difluorophenyl)-5-hydroxy-4-oxo-4H-chromen-7-yl)oxy)acetate

: C₁₇H₁₀F₂O₆

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.bmcl.2013.05.095