5,7-Dihydroxychromone

Base Information

Chemical Name:5,7-Dihydroxychromone
CAS No.:31721-94-5
Molecular Formula:C9H6 O4
Molecular Weight:178.144
Hs Code.:2914400090
ChEMBL ID:CHEMBL3604316
DSSTox Substance ID:DTXSID30185617
Metabolomics Workbench ID:45806
Nikkaji Number:J88.738B
Wikidata:Q27105540
Mol file:31721-94-5.mol

Synonyms:5,7-dihydroxychromone

Suppliers and Price of 5,7-Dihydroxychromone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
5,7-Dihydroxychromone phyproof? Reference Substance
20mg
$ 134.00

Medical Isotopes, Inc.
5,7-dihydroxychromone 98%
20 mg
$ 900.00

DC Chemicals
5,7-dihydroxychromone >98%,StandardReferencesGrade
20 mg
$ 280.00

Crysdot
5,7-Dihydroxychromone 95+%
1g
$ 360.00

ChemScene
5,7-Dihydroxychromone 99.94%
5mg
$ 235.00

ChemScene
5,7-Dihydroxychromone 99.94%
10mg
$ 400.00

Chemenu
5,7-dihydroxy-4H-chromen-4-one 95%
1g
$ 337.00

Cayman Chemical
5,7-Dihydroxychromone
10mg
$ 190.00

Cayman Chemical
5,7-Dihydroxychromone
1mg
$ 39.00

Cayman Chemical
5,7-Dihydroxychromone
5mg
$ 104.00

Total 48 raw suppliers

Chemical Property of 5,7-Dihydroxychromone

Chemical Property:

Vapor Pressure:5.94E-07mmHg at 25°C
Melting Point:232-273℃
Boiling Point:399.4oC at 760 mmHg
PKA:6.57±0.20(Predicted)
Flash Point:170.8oC
PSA：70.67000
Density:1.563g/cm3
LogP:1.20420
Storage Temp.:2-8°C
Solubility.:insoluble in H2O; ≥5.41 mg/mL in EtOH with gentle warming; ≥7.05 mg/mL in DMSO
XLogP3:1.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:0
Exact Mass:178.02660867
Heavy Atom Count:13
Complexity:248

Purity/Quality:

≥98% ^*data from raw suppliers

5,7-Dihydroxychromone phyproof? Reference Substance ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=COC2=CC(=CC(=C2C1=O)O)O
Description 5,7-Dihydroxychromone is a flavone decomposition product that has been found in A. hypogaea and has diverse biological activities, including antimicrobial, antioxidant, and neuroprotective properties. It reduces radial growth of the soil pathogenic fungi R. solani and S. rolfsii (IC50s = 18 and 26 μM, respectively) but has no effect on soil pathogenic bacteria of the genus Bradyrhizobium. 5,7-Dihydroxychromone (0.4, 2, and 10 μM) reduces increases in apoptosis and the levels of reactive oxygen species (ROS) induced by 6-OHDA in SH-SY5Y neuroblastoma cells. It also increases the levels of HO-1, NQO1, and GCLc in SH-SY5Y cells when used at concentrations ranging from 0.08 to 10 μM.

Technology Process of 5,7-Dihydroxychromone

There total 13 articles about 5,7-Dihydroxychromone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.3%

: 480-66-0,67471-34-5
2,4,6-trihydroxyacetophenone

: 124-63-0
methanesulfonyl chloride

: 31721-94-5
5,7-dihydroxy-chromen-4-one

Guidance literature:: With boron trifluoride diethyl etherate; In N,N-dimethyl-formamide; at 20 - 90 ℃; for 3.83h;

Reference yield: 90.3%

: 480-66-0,67471-34-5
2,4,6-trihydroxyacetophenone

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 31721-94-5
5,7-dihydroxy-chromen-4-one

Guidance literature:: With boron trifluoride diethyl etherate; methanesulfonyl chloride; at 20 - 90 ℃; for 3.83333h;
DOI:10.1016/j.tetlet.2010.03.092

Reference yield: 80.0%

: 59887-89-7
7-hydroxy-4H-chromen-4-one

: 31721-94-5
5,7-dihydroxy-chromen-4-one

Guidance literature:: With Ru(CF₃CO₂)2(p-cymene)(H₂O); bis-[(trifluoroacetoxy)iodo]benzene; In trifluoroacetic acid; trifluoroacetic anhydride; at 80 ℃; for 16h;
DOI:10.1021/acs.orglett.5b01138