4-Amino-1-[(2R,3aR,9aR)-3-(benzenesulfonyl-difluoro-methyl)-3-hydroxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-1H-pyrimidin-2-one

Base Information

• Chemical Name: 4-Amino-1-[(2R,3aR,9aR)-3-(benzenesulfonyl-difluoro-methyl)-3-hydroxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-1H-pyrimidin-2-one
• CAS No.: 142887-93-2
• Molecular Formula: C₂₈H₄₃F₂N₃O₈SSi₂
• Molecular Weight: 675.899
• Mol file: 142887-93-2.mol

Synonyms:4-Amino-1-[(2R,3aR,9aR)-3-(benzenesulfonyl-difluoro-methyl)-3-hydroxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-1H-pyrimidin-2-one

Chemical Property of 4-Amino-1-[(2R,3aR,9aR)-3-(benzenesulfonyl-difluoro-methyl)-3-hydroxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-1H-pyrimidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Amino-1-[(2R,3aR,9aR)-3-(benzenesulfonyl-difluoro-methyl)-3-hydroxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-1H-pyrimidin-2-one

There total 3 articles about 4-Amino-1-[(2R,3aR,9aR)-3-(benzenesulfonyl-difluoro-methyl)-3-hydroxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-1H-pyrimidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

1-[(2R,3aR,9aR)-3-(Benzenesulfonyl-difluoro-methyl)-3-hydroxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-4-ethoxy-1H-pyrimidin-2-one (142887-91-0) → 4-Amino-1-[(2R,3aR,9aR)-3-(benzenesulfonyl-difluoro-methyl)-3-hydroxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-1H-pyrimidin-2-one (142887-93-2)

Guidance literature:

With ammonia; In ethanol; at 70 ℃; for 16h;

DOI:10.1016/S0040-4039(00)79824-8

Reference yield:

difluoromethyl phenyl sulfone (1535-65-5) → 4-Amino-1-[(2R,3aR,9aR)-3-(benzenesulfonyl-difluoro-methyl)-3-hydroxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-1H-pyrimidin-2-one (142887-93-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / LiN3)3>2 / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.5 h / -70 °C

2: 69 percent / NH₃ / ethanol / 16 h / 70 °C

With ammonia; lithium hexamethyldisilazane; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol;

DOI:10.1016/S0040-4039(00)79824-8

Reference yield:

4-ethoxy-1-<3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-erythro-2-pentulofuranosyl>-2(1H)-pyrimidinone (113648-22-9) → 4-Amino-1-[(2R,3aR,9aR)-3-(benzenesulfonyl-difluoro-methyl)-3-hydroxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-1H-pyrimidin-2-one (142887-93-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / LiN3)3>2 / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.5 h / -70 °C

2: 69 percent / NH₃ / ethanol / 16 h / 70 °C

With ammonia; lithium hexamethyldisilazane; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol;

DOI:10.1016/S0040-4039(00)79824-8

upstream raw materials:

1-[(2R,3aR,9aR)-3-(Benzenesulfonyl-difluoro-methyl)-3-hydroxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-4-ethoxy-1H-pyrimidin-2-one

difluoromethyl phenyl sulfone

4-ethoxy-1-<3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-erythro-2-pentulofuranosyl>-2(1H)-pyrimidinone

Downstream raw materials:

Methanesulfonic acid (2R,3aR,9aR)-3-(benzenesulfonyl-difluoro-methyl)-5,5,7,7-tetraisopropyl-2-(4-methanesulfonylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl ester