Technology Process of (3R,4S)-3,5-diphenyl-4-((S)-1-phenylpropyl)-3,4-dihydro-2H-pyrrole
There total 4 articles about (3R,4S)-3,5-diphenyl-4-((S)-1-phenylpropyl)-3,4-dihydro-2H-pyrrole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium on activated charcoal; ammonium formate; zinc;
In
methanol;
at 20 ℃;
for 8h;
Inert atmosphere;
DOI:10.1021/ol2023196
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: copper(l) chloride; 6-methyl-pyridine-2-carboxylic acid [2'-(3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yloxy)-[1,1']binaphthalenyl-2-yl]-amide / diethyl ether; dichloromethane / 0.17 h / 20 °C / Inert atmosphere
1.2: 2 h / -20 °C / Inert atmosphere
1.3: 24 h / -20 °C / Inert atmosphere
2.1: palladium on activated charcoal; ammonium formate; zinc / methanol / 8 h / 20 °C / Inert atmosphere
With
palladium on activated charcoal; ammonium formate; copper(l) chloride; zinc; 6-methyl-pyridine-2-carboxylic acid [2'-(3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yloxy)-[1,1']binaphthalenyl-2-yl]-amide;
In
methanol; diethyl ether; dichloromethane;
1.1: tandem dual Michael reaction / 1.2: tandem dual Michael reaction / 1.3: tandem dual Michael reaction;
DOI:10.1021/ol2023196
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium diisopropyl amide / diethyl ether / 2 h / -78 °C
1.2: 24 h / -20 °C
2.1: palladium on activated charcoal; ammonium formate; zinc / methanol / 8 h / 20 °C / Inert atmosphere
With
palladium on activated charcoal; ammonium formate; zinc; lithium diisopropyl amide;
In
methanol; diethyl ether;
1.1: Michael reaction;
DOI:10.1021/ol2023196
